| Relationship between chronic atrial fibrillation and worse outcomes in stroke patients after intravenous thrombolysis. | |
| | |
MedLine Citation:
|
PMID: 22084129 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: It is unclear whether stroke patients with atrial fibrillation (AF) are prone to adverse outcomes following treatment with intravenous recombinant tissue plasminogen activator, and whether the burden of AF affects these outcomes. OBJECTIVE: To investigate the contribution of AF (whether it be a first-detected episode of AF or chronic AF) to stroke outcomes in patients treated with intravenous recombinant tissue plasminogen activator. DESIGN: Retrospective study. SETTING: Academic hospital. Patients Consecutive patients with acute ischemic stroke who received intravenous recombinant tissue plasminogen activator within 3 hours from symptom onset were included. Vascular risk factors, stroke characteristics, and outcome measures were compared between patients with and without AF. MAIN OUTCOME MEASURES: Symptomatic intracranial hemorrhage and poor functional recovery (modified Rankin Scale score of >2). RESULTS: Of the 214 patients who were studied (mean [SD] age, 74 [14] years, with 50% of patients being men), 21 had a first-detected episode of AF, and 55 had chronic AF. The incidence of symptomatic intracranial hemorrhage was significantly higher in patients with chronic AF than in patients without AF (16% vs 5%), and the incidence of poor functional recovery was significantly higher in patients with chronic AF than in patients without AF (62% vs 44%). The increase in risk of symptomatic intracranial hemorrhage (but not in poor functional recovery) among patients with chronic AF remained significant after adjusting for age and baseline National Institutes of Health Stroke Scale score (odds ratio, 2.95 [95% CI, 1.12-9.30]). Patients with chronic AF who developed a symptomatic intracranial hemorrhage had a longer duration of AF than those who did not (59 vs 23 months), and patients with chronic AF who had a poor functional recovery had a longer duration of AF than those who did not (36 vs 16 months) (P < .05). By contrast, there were no differences in outcomes between patients with a first-detected episode of AF and those without AF, and between patients with paroxysmal AF and those with persistent or permanent AF. CONCLUSIONS: Patients with chronic AF have worse stroke outcomes than do patients without AF, and the risk for worse outcomes was greater in patients with a longer duration of AF. |
| | |
Authors:
|
Raymond C S Seet; Yi Zhang; Eelco F Wijdicks; Alejandro A Rabinstein |
Related Documents
:
|
17251609 - Can a normal range of elbow movement predict a normal elbow x ray? 17092929 - Pathologic characteristics of the torn human meniscus. 16379579 - Changes in cerebral blood flow from the acute to the chronic phase of severe head injury. 8970549 - Mild traumatic brain injuries in low-risk trauma patients. 10647559 - Persistent occult hypoperfusion is associated with a significant increase in infection ... 22205269 - Investigation of trefoil factor expression in saliva and oral mucosal tissues of patien... 17968519 - S100 as a marker of acute brain ischemia: a systematic review. 6474529 - Risk of stroke in patients with mitral annulus calcification. 1219949 - Neuromuscular abnormalities in the major mental illnesses. i. serum enzyme studies. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of neurology Volume: 68 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 1454-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Mayo Clinic, W8B, 200 First St SW, Rochester, MN 55905. raymond_seet@nus.edu.sg. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prefrontal cortex and executive function impairments in primary breast cancer.
Next Document: Positron emission tomography and neuropathologic estimates of fibrillar amyloid-? in a patient with ...