| Relationship between chromosome 8 alterations and Gleason score in prostatic adenocarcinoma | |
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MedLine Citation:
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PMID: 17134545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the gain of chromosome 8 and c-myc gene and lipoprotein lipase gene status in prostatic adenocarcinoma of Chinese patients, and to analyze the relationship between chromosome 8 alterations and Gleason score of prostatic cancer. METHODS: Formalin-fixed, paraffin-embedded prostatic biopsy tissues from 34 Chinese patients with untreated prostatic adenocarcinoma were studied by three-color fluorescence in situ hybridization (FISH) using ProVysion(TM) probe kit. The materials included 1 case with Gleason score 5, 10 cases with Gleason score 6, 14 cases with Gleason score 7, 4 cases with Gleason score 8 and 5 cases with Gleason score 9. The relationship between Gleason score and chromosome 8 aneusomy, c-myc and lipoprotein lipase gene copy number, including gene amplification or deletion, were analyzed. RESULTS: Seventeen (50%) of the 34 cases studied had gain of chromosome 8, while 21 cases (61.8%) had gain of c-myc gene copy number, 15 cases (44.1%) had lipoprotein lipase gene monosomy, 23 cases (67.6%) had c-myc gene amplification, 21 cases (61.8%) had deletion of lipoprotein lipase gene and 16 cases (47.1%) had lipoprotein lipase gene deletion coupled with c-myc gene amplification. In general, at least one type of chromosome 8 alteration was identified in 85.3% of cases (29/34). Gain of chromosome 8 was strong significant associated with Gleason score (P = 0.0006). A positive correlation between increased c-myc copy number and high Gleason score was also noted (P = 0.0035). On the other hand, loss of lipoprotein lipase gene was negatively correlated with high Gleason score (P = 0.0383). In addition, the association of c-myc gene amplification with high Gleason score was noted after age adjustment (P = 0.0462). CONCLUSIONS: Alterations in chromosome 8 are common in prostatic adenocarcinoma occurring in Chinese patients. There is a correlation between Gleason score and gain of chromosome 8, increased c-myc gene copy number, c-myc gene amplification and lipoprotein lipase gene deletion. C-myc gene amplification accompanied by lipoprotein lipase gene deletion is also a common occurrence in prostatic cancer. Our data suggest that chromosome 8 alterations may play some roles in the development and progression of prostatic adenocarcinoma. |
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Authors:
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Xuan Zeng; Sha-fei Wu; Qun Xu; Yu Xiao; Tong-hua Liu |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Zhonghua bing li xue za zhi Chinese journal of pathology Volume: 35 ISSN: 0529-5807 ISO Abbreviation: Zhonghua Bing Li Xue Za Zhi Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-11-30 Completed Date: 2009-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0005331 Medline TA: Zhonghua Bing Li Xue Za Zhi Country: China |
Other Details:
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Languages: chi Pagination: 523-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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classification,
genetics*,
pathology* Aged Aged, 80 and over Chromosome Aberrations* Chromosomes, Human, Pair 8 / genetics* Gene Deletion Gene Dosage Humans In Situ Hybridization, Fluorescence Lipoprotein Lipase / genetics Male Middle Aged Prostatic Neoplasms / classification, genetics, pathology* Proto-Oncogene Proteins c-myc / genetics |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-myc; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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