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Relationship between the change in left ventricular hypertrophy and asleep blood pressure after sodium restriction and/or diuretic treatment.
MedLine Citation:
PMID:  21928544     Owner:  NLM     Status:  In-Process    
BACKGROUND: Salt restriction and/or diuretic treatment convert nondippers to dippers; however, few reports have compared the relationships among the changes in asleep ambulatory blood pressure, left ventricular mass index(LVMI), and relative wall thickness between nondippers and dippers.
METHODS: We treated 30 never-treated hypertensive outpatients [office blood pressure (OBP) > 140/90 mmHg]with salt restriction (NaCl < 6 g/day) and/or indapamide(1 or 2 mg/day) to control both OBP (< 140/90 mmHg) and home BP (< 135/85 mmHg) for 4 months. OBP and home BP (measured monthly), ambulatory blood pressure, and echocardiogram (measured at the baseline and at the end of the treatment period) were evaluated.
RESULTS: There were 12 nondippers [asleep/awake systolic BP (SBP) ratio > 0.90] and 18 dippers. Asleep SBP/diastolic BP decreased in both nondippers(149 ± 19/81 ± 16 – 126 ± 22/74 ± 13 mmHg) and dippers(129 ± 9/81 ± 8 – 121 ± 9/74 ± 10 mmHg; P between groups =0.005/0.11). LVMI significantly decreased in nondippers (116 ± 17.3 – 82 ± 27.8 kg/m2; P = 0.02), but not in dippers (P = 0.31; P between groups =0.11).The change in RWT was significantly different between nondippers (0.50 ± 0.07 – 0.47 ± 0.10) and dippers(0.43 ± 0.07 – 0.45 ± 0.07; P between groups = 0.036).
Joji Ishikawa; Kazuo Eguchi; Satoshi Hoshide; Kazuyuki Shimada; Kazuomi Kario
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  16     ISSN:  1473-5725     ISO Abbreviation:  Blood Press Monit     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-09-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  172-9     Citation Subset:  IM    
Division of Cardiovascular Medicine, Department of Internal Medicine,Jichi Medical University School of Medicine, Tochigi, Japan.
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