| Relationship between cervical mucus interleukin-8 concentrations and vaginal bacteria in pregnancy. | |
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MedLine Citation:
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PMID: 15274649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: High interleukin (IL)-8 concentration in cervical mucus in the second trimester is a risk factor for premature birth. We investigated the relationship between vaginal pathogens and IL-8 in cervical mucus. METHOD OF STUDY: In 501 women with single pregnancy, vaginal secretions were cultured for bacteria and cervical mucus IL-8 concentrations were measured between 20 and 24 gestational weeks. RESULTS: Lactobacillus species were detected in 56.0% of 84 subjects with high IL-8 (> or =377 ng/mL), significantly less often than in 417 subjects with IL-8 below 377 ng/mL (84.7%; P < 0.0001). Anaerobic pathogens were detected in 83.3% of high IL-8 subjects, significantly more often than in normal IL-8 subjects (43.9%; P < 0.0001). By multivariate analysis, cervical IL-8 was significantly high only in subjects without Lactobacillus species; they showed a significantly higher prematurity rate than Lactobacillus-positive subjects. CONCLUSIONS: Absence of vaginal Lactobacilli was associated with increased cervical IL-8 and increased risk of premature delivery. |
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Authors:
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Masatoshi Sakai; Akihiko Ishiyama; Mika Tabata; Yasushi Sasaki; Satoshi Yoneda; Arihiro Shiozaki; Shigeru Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 52 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-27 Completed Date: 2005-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 106-12 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyoma, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervix Mucus / metabolism*, microbiology Female Humans Interleukin-8 / metabolism* Lactobacillus / metabolism Pregnancy Premature Birth / etiology*, metabolism, microbiology Vagina / metabolism, microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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