Document Detail

Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets.
MedLine Citation:
PMID:  19033884     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the hypothesis that cerebral hemoglobin (Hb) oxygenation is related to phosphorylation potential during primary and secondary cerebral energy failure in newborn infants who have experienced birth asphyxia. We subjected newborn piglets to severe transient cerebral hypoxic-ischemia followed by resuscitation and examined cerebral energy metabolism by 31P-magnetic resonance spectroscopy and evaluated changes in cerebral Hb oxygen saturation (ScO2) using full-spectrum near-infrared spectroscopy before, during, and up to 54 h after the hypoxic-ischemic insult. ScO2 was significantly decreased during the hypoxic-ischemic insult compared with baseline values. During secondary energy failure, piglets were separated based on the relationship between the ratio of phosphocreatine to inorganic phosphate and ScO2; those with a negative correlation were less injured than those with a positive correlation. These results indicate that changes in ScO2 as measured by near-infrared spectroscopy are related to phosphorylation potential during secondary energy failure in asphyxiated infants.
Takashi Kusaka; Masaki Ueno; Takanori Miki; Toru Kuboi; Shinji Nakamura; Kosuke Koyano; Sonoko Ijichi; Saneyuki Yasuda; Kensuke Okubo; Kou Kawada; Masanori Namba; Tomoko Nishida; Tadashi Imai; Kenichi Isobe; Susumu Itoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  65     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan.
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MeSH Terms
Animals, Newborn
Energy Metabolism / physiology*
Hemoglobins / metabolism*
Hypoxia-Ischemia, Brain / metabolism*
Magnetic Resonance Spectroscopy
Oxygen / metabolism*
Phosphocreatine / blood
Spectroscopy, Near-Infrared
Reg. No./Substance:
0/Hemoglobins; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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