Document Detail

Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets.
MedLine Citation:
PMID:  14630993     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the validity of the hypothesis that excitatory amino acids are related to phosphorylation potential during primary and secondary cerebral energy failure observed in asphyxiated infants. We report here the results of experiments using newborn piglets subjected to severe transient cerebral hypoxia-ischemia followed by resuscitation. We examined cerebral energy metabolism by phosphorus nuclear magnetic resonance spectroscopy and changes in levels of amino acid neurotransmitters in the cortex by microdialysis before, during, and up to 24 h after the hypoxic-ischemic insult. The concentrations of aspartate, glutamate, taurine, and gamma-aminobutyric acid were significantly elevated during the hypoxic-ischemic insult compared with prebaseline values. Shortly after resuscitation, glutamate, taurine, and gamma-aminobutyric acid concentrations decreased but then began to increase again. These secondary elevations were greater than the primary elevations. A negative linear correlation was found between primary interstitial levels of glutamate and taurine and minimum values of phosphocreatine/inorganic phosphate during the secondary energy failure. The cerebral energy state depended on the time course of changes in excitatory amino acids, suggesting that amino acids play distinct roles during the early and delayed phases of injury.
Takashi Kusaka; Satoshi Matsuura; Yuka Fujikawa; Kensuke Okubo; Kou Kawada; Masanori Namba; Hitoshi Okada; Tadashi Imai; Kenichi Isobe; Susumu Itoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-11-19
Journal Detail:
Title:  Pediatric research     Volume:  55     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-22     Completed Date:  2004-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Maternal and Perinatal Center, Kagawa Medical University, Mikicho 1750-1, Kitagun, Kagawa 761-0793, Japan.
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MeSH Terms
Amino Acids / metabolism*
Animals, Newborn
Brain / metabolism*
Energy Metabolism / physiology*
Extracellular Fluid / metabolism
Hypoxia-Ischemia, Brain / metabolism*
Magnetic Resonance Spectroscopy
Phosphates / metabolism
Phosphocreatine / metabolism
Phosphorus Isotopes / diagnostic use
Reg. No./Substance:
0/Amino Acids; 0/Phosphates; 0/Phosphorus Isotopes; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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