Document Detail

Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension.
MedLine Citation:
PMID:  17389264     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sympathetic activation has been implicated in the development of left ventricular hypertrophy (LVH). However, the relationship between sympathetic activation and LV mass (LVM) has not been clearly defined across a range of arterial pressure measurements. The present study was planned to determine that relationship, using cardiac magnetic resonance imaging to accurately quantify LVM, in hypertensive patients with and without LVH and in normal subjects.
METHODS AND RESULTS: Twenty-four patients with uncomplicated and untreated essential hypertension (LVH[-]) were compared with 25 patients with essential hypertension and left ventricular hypertrophy (LVH[+]) and 24 normal control subjects. Resting muscle sympathetic nerve activity was quantified as multiunit bursts and single units. Cardiac magnetic resonance imaging-determined LVM was indexed to body surface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1 g/m2, a value between those of the LVH[+] (91+/-3.4 g/m2) and normal control (57+/-2.2 g/m2) groups, respectively. The sympathetic activity in the LVH[-] group (53+/-1.3 bursts per 100 cardiac beats and 63+/-1.6 impulses per 100 cardiac beats) was between (at least P<0.001) those of the LVH[+] (66+/-1.7 bursts per 100 cardiac beats and 77+/-2.2 impulses per 100 cardiac beats) and normal control (39+/-3.0 bursts per 100 cardiac beats and 45+/-3.4 impulses per 100 cardiac beats) groups. Significant positive correlation existed between sympathetic activity and LVM index in the LVH[-] and LVH[+] groups (at least r=0.76, P<0.0001) but not in the normal control group. However, no consistent relationship existed between arterial blood pressure and sympathetic activity or LVM index.
CONCLUSIONS: These findings further support the hypothesis that central sympathetic activation is associated with the development of LVH in human hypertension.
Joanna Burns; Mohan U Sivananthan; Stephen G Ball; Alan F Mackintosh; David A S G Mary; John P Greenwood
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-26
Journal Detail:
Title:  Circulation     Volume:  115     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-05-01     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1999-2005     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Volume
Heart Ventricles / pathology*,  physiopathology
Hypertension / complications,  diagnosis*,  physiopathology*
Hypertrophy, Left Ventricular / complications,  diagnosis*,  physiopathology*
Magnetic Resonance Imaging
Middle Aged
Organ Size
Predictive Value of Tests
Reference Values
Sympathetic Nervous System / physiopathology*
Grant Support
PG/03/001/14631//British Heart Foundation
Comment In:
Circulation. 2007 Oct 23;116(17):e416; author reply e417   [PMID:  17965398 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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