| Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension. | |
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MedLine Citation:
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PMID: 17389264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sympathetic activation has been implicated in the development of left ventricular hypertrophy (LVH). However, the relationship between sympathetic activation and LV mass (LVM) has not been clearly defined across a range of arterial pressure measurements. The present study was planned to determine that relationship, using cardiac magnetic resonance imaging to accurately quantify LVM, in hypertensive patients with and without LVH and in normal subjects. METHODS AND RESULTS: Twenty-four patients with uncomplicated and untreated essential hypertension (LVH[-]) were compared with 25 patients with essential hypertension and left ventricular hypertrophy (LVH[+]) and 24 normal control subjects. Resting muscle sympathetic nerve activity was quantified as multiunit bursts and single units. Cardiac magnetic resonance imaging-determined LVM was indexed to body surface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1 g/m2, a value between those of the LVH[+] (91+/-3.4 g/m2) and normal control (57+/-2.2 g/m2) groups, respectively. The sympathetic activity in the LVH[-] group (53+/-1.3 bursts per 100 cardiac beats and 63+/-1.6 impulses per 100 cardiac beats) was between (at least P<0.001) those of the LVH[+] (66+/-1.7 bursts per 100 cardiac beats and 77+/-2.2 impulses per 100 cardiac beats) and normal control (39+/-3.0 bursts per 100 cardiac beats and 45+/-3.4 impulses per 100 cardiac beats) groups. Significant positive correlation existed between sympathetic activity and LVM index in the LVH[-] and LVH[+] groups (at least r=0.76, P<0.0001) but not in the normal control group. However, no consistent relationship existed between arterial blood pressure and sympathetic activity or LVM index. CONCLUSIONS: These findings further support the hypothesis that central sympathetic activation is associated with the development of LVH in human hypertension. |
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Authors:
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Joanna Burns; Mohan U Sivananthan; Stephen G Ball; Alan F Mackintosh; David A S G Mary; John P Greenwood |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-26 |
Journal Detail:
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Title: Circulation Volume: 115 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-05-01 Revised Date: 2008-01-29 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1999-2005 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Volume Electrophysiology Female Heart Ventricles / pathology*, physiopathology Humans Hypertension / complications, diagnosis*, physiopathology* Hypertrophy, Left Ventricular / complications, diagnosis*, physiopathology* Magnetic Resonance Imaging Male Middle Aged Organ Size Predictive Value of Tests Reference Values Sympathetic Nervous System / physiopathology* |
| Comments/Corrections | |
Comment In:
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Circulation. 2007 Oct 23;116(17):e416; author reply e417
[PMID:
17965398
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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