| Relationship between central and peripheral atherosclerosis and left ventricular dysfunction in a community population. | |
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MedLine Citation:
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PMID: 21708875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to determine the relationships between resting left ventricular (LV) wall motion abnormalities (WMAs), aortic plaque, and peripheral artery disease (PAD) in a community cohort. A total of 1726 Framingham Heart Study Offspring Cohort participants (806 males, 65 ± 9 years) underwent cardiovascular magnetic resonance with quantification of aortic plaque volume and assessment of regional left ventricular systolic function. Claudication, lower extremity revascularization, and ankle-brachial index (ABI) were recorded at the most contemporaneous examination visit. WMAs were associated with greater aortic plaque burden, decreased ABI, and claudication in age- and sex-adjusted analyses (all p < 0.001), which were not significant after adjustment for cardiovascular risk factors. In age- and sex-adjusted analyses, both the presence (p < 0.001) and volume of aortic plaque were associated with decreased ABI (p < 0.001). After multivariable adjustment, an ABI ≤ 0.9 or prior revascularization was associated with a threefold odds of aortic plaque (p = 0.0083). Plaque volume significantly increased with decreasing ABI in multivariable-adjusted analyses (p < 0.0001). In this free-living population, associations of WMAs with aortic plaque burden and clinical measures of PAD were attenuated after adjustment for coronary heart disease risk factors. Aortic plaque volume and ABI remained strongly negatively correlated after multivariable adjustment. Our findings suggest that the association between coronary heart disease and non-coronary atherosclerosis is explained by cardiovascular risk factors. Aortic atherosclerosis and PAD remain strongly associated after multivariable adjustment, suggesting shared mechanisms beyond those captured by traditional risk factors. |
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Authors:
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Connie W Tsao; Philimon Gona; Carol Salton; Joanne M Murabito; Noriko Oyama; Peter G Danias; Christopher J O'Donnell; Warren J Manning; Susan B Yeon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-27 |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 16 ISSN: 1477-0377 ISO Abbreviation: Vasc Med Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-10 Completed Date: 2011-12-13 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Harvard-Thorndike Laboratory and Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Ankle Brachial Index Aortic Diseases / diagnosis, epidemiology*, physiopathology Atherosclerosis / diagnosis, epidemiology*, physiopathology Chi-Square Distribution Cohort Studies Coronary Artery Disease / diagnosis, epidemiology*, physiopathology Female Humans Linear Models Logistic Models Magnetic Resonance Imaging Male Massachusetts / epidemiology Middle Aged Odds Ratio Peripheral Arterial Disease / diagnosis, epidemiology*, physiopathology Prevalence Risk Assessment Risk Factors Stroke Volume Ventricular Dysfunction, Left / diagnosis, epidemiology*, physiopathology Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; N01HC25195/HL/NHLBI NIH HHS; R01 HL070279-04S1/HL/NHLBI NIH HHS; R01 HL70279/HL/NHLBI NIH HHS; T32 HL007374-34/HL/NHLBI NIH HHS; T32 HL07374/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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