Document Detail

Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
MedLine Citation:
PMID:  7640037     Owner:  NLM     Status:  MEDLINE    
The relationship between cathepsin D and other pathological or biological prognostic parameters has not yet been defined through systematic studies in breast cancer. The aim of the present investigation was to define the relationship between cathepsin D and nodal status, tumour size, steroid receptors and tumour grade in a wide patient series. Cytosol cathepsin D was assayed with an immunoradiometric assay in tumour samples from 1752 patients. A statistically significant, but not biologically meaningful association was found between cathepsin D and both tumour size and grade. Cathepsin D was significantly higher in node-positive than in node-negative tumours. However, cathepsin D is not of great use in order to predict the risk of axillary metastases in individual patients, due to overlapping of cathepsin D values between node-positive and node-negative cases. A significant, direct association was found between cathepsin D and both oestrogen receptor and progesterone receptor cytosol levels. Nevertheless, preliminary data indicate that cathepsin D and steroid receptors provide independent prognostic information.
M Gion; R Mione; R Dittadi; M Romanelli; L Pappagallo; G Capitanio; U Friede; R Barbazza; A Visonà; S Dante
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  31A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1995  
Date Detail:
Created Date:  1995-09-18     Completed Date:  1995-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Divisione di Anatomia Patologica, Ospedale S. Bortolo, Vicenza, Italy.
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MeSH Terms
Aged, 80 and over
Breast Neoplasms / enzymology*,  metabolism,  pathology
Cathepsin D / metabolism*
Cytosol / metabolism
Immunoradiometric Assay
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; EC D

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