| Relationship between carnitine, fatty acids and insulin resistance. | |
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MedLine Citation:
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PMID: 20530934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased plasma free fatty acid (FFA) levels are a feature of insulin resistance and type 2 diabetes. The aim of the present study was to assess the effect of L-carnitine supplementation on plasma lipids and the expression of enzymes in peripheral mononucleated cells (PMNC) involved in the regulation of fatty acid and glucose oxidation. L-Carnitine supplementation of 2 g/day resulted in a significant decrease in plasma FFA and in a less pronounced diminution of the plasma triacylglycerols. In addition, a concomitant increase in the relative mRNA abundances of carnitine acyltransferases (5- to 10-fold) and of the carnitine carrier OCTN2 (12-fold) in PMNC of pregnant women was found. The results of the present study provide evidence that L-carnitine supplementation in pregnancy (2 g/day) avoids a striking increase in plasma FFA, which are thought to be the main cause of insulin resistance and consequently gestational diabetes mellitus. |
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Authors:
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Alfred Lohninger; U Radler; S Jinniate; S Lohninger; H Karlic; S Lechner; D Mascher; A Tammaa; H Salzer |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-19 |
Journal Detail:
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Title: Gynäkologisch-geburtshilfliche Rundschau Volume: 49 ISSN: 1423-0011 ISO Abbreviation: Gynakol Geburtshilfliche Rundsch Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9212667 Medline TA: Gynakol Geburtshilfliche Rundsch Country: Switzerland |
Other Details:
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Languages: eng Pagination: 230-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Center for Physiology and Pathophysiology, Institute of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, Vienna, Austria. alfred.lohninger@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carnitine
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analogs & derivatives,
blood,
therapeutic use* Carnitine O-Acetyltransferase / blood, genetics Carnitine O-Palmitoyltransferase / blood, genetics Diabetes, Gestational / drug therapy*, genetics, physiopathology Fatty Acids, Nonesterified / blood* Female Gene Expression Regulation / physiology Humans Infant, Newborn Insulin Resistance / physiology* Monocytes / drug effects, physiology Organic Cation Transport Proteins / blood, genetics Pregnancy Pregnancy Trimester, Second RNA, Messenger / genetics |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Organic Cation Transport Proteins; 0/RNA, Messenger; 0/SLC22A5 protein, human; 0/acylcarnitine; 541-15-1/Carnitine; EC 2.3.1.21/Carnitine O-Palmitoyltransferase; EC 2.3.1.7/Carnitine O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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