| Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20185862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that cardiovascular autonomic neuropathy (CAN) in Type 2 diabetes is a risk factor of coronary artery calcification (CAC), in this cross-sectional study, 118 patients (60 males, 58 females) with type 2 diabetes mellitus were randomly selected from the diabetes clinic of Kyungpook National University Hospital, Daegu, Korea, between January, 2008 and September, 2008. The subjects, whose mean age was 56.9+/-1.1 years, were tested for CAN by Ewing's method which employs five non-invasive tests of autonomic function. The coronary calcium score (CCS) was determined by Multi Detector-row Computed Tomography (MDCT). Statistical analysis was performed by using SPSS 13.0 (SPSS, Inc., Chicago,-Illinois). CAN was found in 31/118 (26.3%) patients. Compared to the patients without CAN, the patients with CAN were significantly older and had significantly higher triglyceride levels, blood pressure, pulse pressure, fasting c-peptide levels, CAN scores, and log-transformed coronary calcium scores [ln(CCS+1)]. The CAN scores correlated positively with ln(CCS+1) values (r = 0.214; P = 0.028). Multiple regression analysis using ln(CCS+1) as a dependent variable showed that CAN score (beta coefficient 0.623, 95% CI 0.059 approximately 1.188, P = 0.031) associated independently with ln(CCS+1). In conclusion, CAN was associated independently with CAC, which suggests that CAN is a risk factor of coronary atherosclerosis in patients with type 2 diabetes. This may help to explain the excess cardiovascular mortality seen in diabetic patients with CAN. |
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Authors:
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Seong-Su Moon; Yeon-Kyung Choi; Hyun-Ae Seo; Jae-Han Jeon; Jung-Eun Lee; Ji-Yun Jeong; Ju-Young Lee; Duk-Hee Lee; Wan-Ju Park; Jung-Guk Kim; Bo-Wan Kim; In-Kyu Lee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-26 |
Journal Detail:
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Title: Endocrine journal Volume: 57 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 445-54 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Jungu, Daegu, Korea. drmoonss@hanmail.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcinosis
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epidemiology,
etiology*,
radiography Cardiomyopathies / epidemiology, etiology*, radiography Coronary Vessels / pathology* Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications*, epidemiology, radiography Diabetic Neuropathies / complications*, epidemiology, radiography Female Heart / innervation*, radiography Humans Male Middle Aged Prevalence Regression Analysis Risk Factors Tomography, X-Ray Computed / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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