| Relationship between cardiopulmonary response to exercise and adiposity in survivors of childhood malignancy. | |
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MedLine Citation:
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PMID: 9166019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many long term sequelae result from previous treatment for malignancy in childhood. However, little information exists on cardiopulmonary response and energy expenditure during exercise and their possible associations with excess body fat. Measurements of body composition and exercise capacity both at low intensity and maximal aerobic capacity were made on 56 long term survivors of childhood malignancy (35 survivors of acute lymphoblastic leukaemia (ALL) and 21 survivors of other malignancies) and 32 siblings acting as controls. Female survivors of ALL had significantly greater mean (SD) body fat than survivors of other malignancies and siblings (32.5 (6.4)% v 24.3 (4.4)% and 26.3 (8.5)% respectively, p < 0.005). Energy expenditure at low intensity exercise was reduced in survivors of ALL, and negatively correlated with body fat after controlling for weight (partial r range -0.21 to -0.47, p < 0.05). Stroke volume, measured indirectly, was reduced and heart rate raised in ALL survivors at sub-maximal exercise levels. Peak oxygen consumption was significantly reduced in girls and boys treated for ALL compared with siblings (30.5 v 41.3 ml/kg/min for girls, p < 0.05 and 39.9 v 47.6 ml/kg/min for boys, p < 0.05 respectively). Reduced exercise capacity may account in part for the excess adiposity observed in long term survivors of ALL. |
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Authors:
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J T Warner; W Bell; D K Webb; J W Gregory |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood Volume: 76 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 298-303 Citation Subset: AIM; IM |
Affiliation:
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University of Wales College of Medicine, Heath Park, Cardiff. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Body Composition Child Exercise / physiology* Exercise Test Female Heart / physiopathology* Humans Leukemia, Myeloid, Acute / physiopathology Lung / physiopathology* Male Neoplasms / complications, physiopathology* Obesity / physiopathology Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications, physiopathology Respiratory Function Tests Survivors* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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