| Relationship between bolus transit and LES-relaxation studied with concurrent impedance and manometry. | |
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MedLine Citation:
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PMID: 16608028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Neuromuscular mechanisms regulating esophageal bolus transport are well studied. However, detailed data about the relationship between bolus transit and lower esophageal sphincter (LES)-relaxation during conventional motility testing are still lacking. METHODOLOGY: We performed systematic studies in 25 normal subjects, employing a catheter that integrates the two techniques impedancometry and manometry in a single instrument for simultaneous recording and analysis of the relationship between bolus transit and LES relaxation after swallowing saline or yogurt. RESULTS: 195 swallows were analyzed. LES relaxation occurred frequently later than UES relaxation. The mean latency between bolus entry into the esophagus and LES relaxation was 3.6 +0.2 sec. Two types of swallow-induced LES relaxation were observed: (a) LES relaxation preceding bolus transit (46 cases or 24%) and (b) LES relaxation occurring during bolus transit (149 cases or 76%). In the later case, during 114 (76%) cases of this deglutition, the position of the bolus was very close to the LES. CONCLUSIONS: During deglutition, LES relaxation seems to be modulated by bolus transit and occurs predominantly upon arrival of the bolus in the distal esophagus. |
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Authors:
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H N Nguyen; G R Domingues; R Winograd; F Lammert; J Silny; S Matern |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 53 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2006 Mar-Apr |
Date Detail:
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Created Date: 2006-04-12 Completed Date: 2006-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 218-23 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Gastroenterology and Helmholtz Institute of Biomedical Engineering University of Technology RWTH-Aachen, Germany. huan.nguyen@SK-MG.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Deglutition / physiology* Electric Impedance* Equipment Design Esophageal Sphincter, Lower / physiology* Female Humans Male Manometry / instrumentation* Muscle Relaxation / physiology* Peristalsis / physiology Reference Values |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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