Document Detail

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study.
MedLine Citation:
PMID:  17136108     Owner:  NLM     Status:  MEDLINE    
Blood pressure (BP) is one of the most important contributing factors to pulse wave velocity (PWV), a classic measure of arterial stiffness. Although there have been many non-invasive studies to show the relation between arterial stiffness and BP, the results are controversial. The aim of this study is to evaluate the role of BP as an influencing factor on PWV using invasive method. We observed 174 normotensive and untreated hypertensive subjects using coronary angiography. Arterial stiffness was assessed through aorto-femoral PWV by foot-to-foot velocity method using fluid-filled system. And BP was measured by pressure wave at the right common femoral artery. From univariate analysis, age, diabetes mellitus (DM), hypertension, waist, waist-to-hip ratio, total cholesterol-to-high-density lipoprotein cholesterol ratio, systolic BP (SBP), pulse pressure (PP) and mean arterial pressure (MAP) showed significant association with PWV. To avoid multiple colinearity among SBP, PP and MAP, we performed multiple regression analysis predicting PWV thrice. Age, DM and each BP were significantly and consistently correlated to PWV. In the first and third modules, compared to age, SBP and MAP were less strong predictors, respectively. However, PP was the stronger predictor than age and DM in the second module. Lastly, we simultaneously forced MAP and PP with other variables in the fourth multivariate analysis. Age, DM and PP remained significantly correlated with PWV, but the significance of MAP was lost. This is the first invasive study to suggest that PP has the strongest correlation with PWV among a variety of BP parameters.
E J Kim; C G Park; J S Park; S Y Suh; C U Choi; J W Kim; S H Kim; H E Lim; S W Rha; H S Seo; D J Oh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-30
Journal Detail:
Title:  Journal of human hypertension     Volume:  21     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-14     Completed Date:  2007-03-12     Revised Date:  2010-01-04    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea.
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MeSH Terms
Age Factors
Blood Flow Velocity / physiology*
Blood Pressure*
Cholesterol, HDL / blood
Diabetes Mellitus / physiopathology
Heart Rate
Hypertension / physiopathology*
Middle Aged
Pulsatile Flow / physiology*
Sex Characteristics
Reg. No./Substance:
0/Cholesterol, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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