Document Detail

Relationship between blood pressure and depression in the elderly. The Three-City Study.
MedLine Citation:
PMID:  18698210     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the relationship between blood pressure and depression in a large sample of noninstitutionalized elderly people. METHODS: Cross-sectional community-based study in 9294 participants aged 65 years and over, living at home, in three French cities (Bordeaux, Dijon and Montpellier). Participants were categorized as depressive, based on three different markers of depression. Multiple linear regression analyses of the relation between depression and mean systolic and diastolic blood pressure values were conducted, taking into account potential confounders like age, sex, education, smoking, alcohol consumption, body mass index and history of cardiovascular events. RESULTS: Our working sample had a mean age (SD) of 73.7 (5.0) years, and included 60.7% of women. Overall, 31% of participants met the criteria for depression, 77.5% had hypertension, and 49.5% were on antihypertensive drugs. Analyses showed lower systolic and diastolic blood pressure values in depressive individuals compared with nondepressive ones, in both men (systolic blood pressure 148.2 versus 151.8 mmHg, P < 0.002; diastolic blood pressure 83.0 versus 84.7 mmHg, P = 0.003) and women (systolic blood pressure 141.7 versus 144.7 mmHg, P < 0.0001; diastolic blood pressure 80.7 versus 81.4 mmHg, P < 0.02). These associations were independent of age and of use of antihypertensive or psychotropic agents. CONCLUSION: In a large sample of elderly individuals from the general population, depressive individuals had lower blood pressure values than nondepressive ones, independent of medications and of history of cardiovascular events.
Hermine Lenoir; Jean-Marc Lacombe; Carole Dufouil; Pierre Ducimetière; Olivier Hanon; Karen Ritchie; Jean-François Dartigues; Annick Alpérovitch; Christophe Tzourio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1765-72     Citation Subset:  IM    
INSERM U708, and Department of Geriatrics, Broca Hospital, 54-56 Rue Pascal, Paris, France.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure*
Cross-Sectional Studies
Depression / diagnosis,  drug therapy,  epidemiology*
France / epidemiology
Hypertension / drug therapy,  epidemiology*,  psychology*
Linear Models
Psychotropic Drugs / therapeutic use
Urban Population / statistics & numerical data
Reg. No./Substance:
0/Antihypertensive Agents; 0/Psychotropic Drugs
Comment In:
J Hypertens. 2008 Sep;26(9):1738-9   [PMID:  18698205 ]

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