Document Detail


Relationship between blood alcohol concentration and carbohydrate-deficient transferrin among drivers.
MedLine Citation:
PMID:  16002036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbohydrate-deficient transferrin (CDT) was quantified in 408 blood specimens, randomly selected from 1260 drivers apprehended and submitted to blood alcohol concentration (BAC) determination. The first step of the study was to observe whether a BAC based pre-evaluation was relevant for deciding to test drivers for chronic alcohol abuse. For this purpose, the diagnosis of chronic alcohol abuse was verified by CDT quantification, with a voluntary high positive cut-off fixed at 3% for high specificity. The results display a significant increase in the part of chronic alcohol abusers with respect to increasing BAC: a few alcohol abusers were present in the BAC category below 0.5 g/L, and their frequency increased to 47 and 67% when BAC was between 3 and 3.5 g/L and above 3.5 g/L, respectively. Secondly, the usefulness of the biomarker CDT in the traffic safety context was investigated by observing whether drivers with abnormally increased CDT value had also higher BAC. The average BAC was 1.32 g/L in drivers with CDT below 1%, and increased to 2.28 g/L in drivers with CDT above 3%. Statistical analysis showed evidence of a monotone increasing link between BAC and CDT (P<0.0001). We confirmed here the relevance of BAC-based pre-evaluation before testing chronic alcohol abuse among drivers, and demonstrated that CDT is a biomarker suitable for traffic safety context, as drivers with increased CDT had significantly higher BAC.
Authors:
Brice M R Appenzeller; Serge Schneider; Armand Maul; Robert Wennig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-03
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  79     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-08     Completed Date:  2006-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Affiliation:
Centre de Recherche Public de la Santé, Laboratoire National de Santé, Division de Toxicologie, Université du Luxembourg, Campus Limpertsberg, 162a, avenue de la Faïencerie, L-1511 Luxembourg. brice.appenzeller@cu.lu
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MeSH Terms
Descriptor/Qualifier:
Accidents, Traffic / prevention & control
Adult
Alcoholic Intoxication / blood
Alcoholism / diagnosis*
Automobile Driving*
Ethanol / blood*
Female
Humans
Male
Transferrin / analogs & derivatives,  analysis
Chemical
Reg. No./Substance:
0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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