Document Detail

Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis.
MedLine Citation:
PMID:  15881282     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Basal thinning of the interventricular septum (IVS) and atrioventricular block (AVB) are characteristic features of cardiac sarcoidosis. Since the conduction system passes along IVS, it has been considered that a close connection exists between basal thinning of IVS and AVB. However, neither the incidence of cases showing basal thinning of IVS nor the relation between it and AVB has been clarified. We thus investigated to elucidate these two issues. METHODS: Thirty-five patients with cardiac sarcoidosis were selected for this study and underwent echocardiographic examination. The wall thickness of IVS was measured at a site 1 cm below the aortic valve inserted point of IVS. Thickness of this site < or = 5 mm was defined as thinning. Twelve-lead and Holter electrocardiograms were obtained to determine the presence/absence and degree of AVB. RESULTS: Basal thinning of IVS was noted in 7 of the 35 patients (20%). AVB was present in 4 of these 7 (57%), and was first degree in 3 (43%) and third degree in one (14%). AVB was not present in 3 patients. Basal thinning of IVS was not apparent in 28 of the 35 patients (80%). AVB was observed in 14 of the 28 patients, 3 had first degree block, 2 had second degree block, and 9 had third degree block. AVB was not observed in 14 of the 28 patients. CONCLUSIONS: These results clarified that basal thinning of IVS is not as common as previously thought in cardiac sarcoidosis, basal thinning of IVS and the presence/absence and degree of AVB are not necessarily correlated.
Akihisa Uemura; Shin-ichiro Morimoto; Yasuchika Kato; Shinya Hiramitsu; Masatsugu Ohtsuki; Shigeru Kato; Atsushi Sugiura; Kenji Miyagishima; Masatsugu Iwase; Hitoshi Hishida
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders     Volume:  22     ISSN:  1124-0490     ISO Abbreviation:  Sarcoidosis Vasc Diffuse Lung Dis     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610928     Medline TA:  Sarcoidosis Vasc Diffuse Lung Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  63-5     Citation Subset:  IM    
Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
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MeSH Terms
Heart Block / etiology*,  pathology*
Heart Septum / pathology*,  ultrasonography
Middle Aged
Sarcoidosis / complications*,  ultrasonography

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