Document Detail

Relationship between basal serum gastrin concentrations and gastric acid secretion in peptic ulcer disease.
MedLine Citation:
PMID:  7233069     Owner:  NLM     Status:  MEDLINE    
In large groups of control subjects and gastric, prepyloric, and duodenal ulcer patients basal gastrin concentration as basal and maximal acid output was measured. All groups had equal basal gastrin concentrations, except gastric ulcer patients, who had higher values (p less than 0.001). A significant negative correlation was found between acid output and basal gastrin in controls and prepyloric ulcer patients. In duodenal ulcer a similar correlation was seen only after exclusion of gastrin and basal acid hypersecretors, and in gastric ulcer no correlation could be found. The characteristic pattern for gastrin and acid secretion was in prepyloric ulcer patients almost like that in controls, whereas gastric ulcer patients seemed more heterogeneous. In duodenal ulcer differences may be explained by a defective feedback inhibition of acid.
J Steen; M Herning; P M Christiansen; J F Rehfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  15     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  949-52     Citation Subset:  IM    
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MeSH Terms
Duodenal Ulcer / physiopathology
Gastric Acid / secretion*
Gastrins / blood*
Middle Aged
Peptic Ulcer / blood,  physiopathology*
Stomach Ulcer / physiopathology
Reg. No./Substance:

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