Document Detail


Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese.
MedLine Citation:
PMID:  23038697     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients.Methods. Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations as well as between clinical manifestations were also performed without any prior clustering.Results. Three separate autoantibody clusters were identified, each with significantly different clinical manifestations. Cluster 1 was characterized by anti-dsDNA and the greatest prevalence of renal disorder but the lowest frequencies of other clinical manifestations. Cluster 2 was represented by the predominance of anti-Smith, anti-RNP and aPL, with greater prevalence of malar rash, oral ulcers, arthritis and serositis. Cluster 3 was characterized by anti-Ro and anti-La with greater prevalence of discoid rash, photosensitivity and haematological involvement. Individual association analysis also revealed similar findings. Patients of clusters 2 and 3 were more closely related, while cluster 1 was more distinct, associated with renal disorder only and negatively associated or not associated with other manifestations.Conclusion. We conclude that autoantibody clustering and clinical subsets exist in SLE patients of our locality. These clusters may be viewed as a bipolar spectrum of related autoantibody and clinical manifestations. At one end are patients with over-representation of anti-dsDNA and renal disorder, while at the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and anti-Ro/anti-La) with overlapping of other clinical manifestations.
Authors:
Philip Hei Li; Wilfred Hing Sang Wong; Tsz Leung Lee; Chak Sing Lau; Tak Mao Chan; Alexander Moon Ho Leung; Kwok Lung Tong; Niko Kei Chiu Tse; Chi Chiu Mok; Sik Nin Wong; Ka Wing Lee; Marco Hok Kung Ho; Pamela Pui Wah Lee; Chun Yin Chong; Raymond Woon Sing Wong; Mo Yin Mok; Shirley King Yee Ying; Samuel Ka Shun Fung; Wai Ming Lai; Wanling Yang; Yu-Lung Lau
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  -     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Paediatrics and Adolescent Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Department of Medicine, Queen Elizabeth Hospital, Department of Medicine, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Department of Medicine, Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital and 8Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong.
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