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Relationship between arterial oxygen saturation and hematocrit, and effect of slow deep breathing on oxygen saturation in himalayan high altitude populations.
MedLine Citation:
PMID:  23434958     Owner:  NLM     Status:  In-Data-Review    
Backgroud The oxygen saturation of haemoglobin is reduced in high altitude-living organisms. Increase in the hematocrit is responsible for rise in the hemoglobin concentration so that the oxygen carrying capacity in the hypobaric hypoxic subject is elevated. Objectives To compare two different high altitude populations, in order to study the relationship between arterial oxygen saturation and hematocrit. Methods lIn the cross-sectional study of two populations residing at altitude of 2800 m and 3760 m are compared for the difference in hematocrit. The oxygen carrying capacity of arterial haemoglobin (SaO2) is determined by pulse oximetry. The sample is drawn from the natives of two small villages, Thini at Jomsom (2800 m) and Jharkot (3760 m) in Mustang district of Nepal. The natives at 2800 m are termed as lower high altitude population and local residents at 3760 m are said to be higher altitude population in this study. The sample blood was drawn by venipuncture and packed cell volume was determined by Wintrobe's method. Results The hematocrit obtained from 3760 m altitude population and the lower high altitude population at altitude of 2800 m differ significantly with the p value < 0.0001and the SaO2 in both the population fails to show any difference with p value > 0.05. Deep breathing exercise in these populations however increased SaO2 significantly. Conclusion The higher altitude natives have greater arterial oxygen saturation than lower altitude population which is due to rise in red cell concentration. The slow deep breathing raises oxygen saturation irrespective of altitude.
O Nepal; B R Pokharel; K Khanal; S L Mallik; B K Kapoor; R Koju
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kathmandu University medical journal (KUMJ)     Volume:  10     ISSN:  1812-2078     ISO Abbreviation:  Kathmandu Univ Med J (KUMJ)     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2013-02-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101215359     Medline TA:  Kathmandu Univ Med J (KUMJ)     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  30-4     Citation Subset:  IM    
Department of Physiology, Dhulikhel Hospital, kathmandu University Hospital Kathmandu University Medical School, Dhulikhel Kavre, Nepal.
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