Document Detail

Relationship between arterial and end-tidal carbon dioxide pressure during controlled ventilation in porcine neonates.
MedLine Citation:
PMID:  8726147     Owner:  NLM     Status:  MEDLINE    
To investigate the validity of ETCO2 in porcine neonates, which have been frequently used as an experimental model for human neonates, the relationship between arterial (PaCO2) and end-tidal PCO2 (ETCO2) in porcine neonates was examined under different respiratory conditions by regulating both inspiratory flow and positive end expiratory pressure (PEEP). The difference between PaCO2 and ETCO2 widened significantly, according to the significant decrease in tidal volume/body weight ratio (TV/BW) caused by the increase of PEEP. A lower correlation between PaCO2 and ETCO2 was observed in < 6 ml/kg than in > or = 6 ml/kg TV/BW. It therefore seems reasonable to conclude that, in porcine neonates, the valid ETCO2 measurements corresponding to PaCO2 would be obtained at > or = 6 ml/kg TV/BW.
H Sakamoto; C Kubota; K Misumi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental animals / Japanese Association for Laboratory Animal Science     Volume:  45     ISSN:  1341-1357     ISO Abbreviation:  Exp. Anim.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  9604830     Medline TA:  Exp Anim     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Body Weight
Carbon Dioxide / blood*
Positive-Pressure Respiration
Respiration, Artificial*
Tidal Volume*
Reg. No./Substance:
142M471B3J/Carbon Dioxide

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