Document Detail

Relationship between apnoea-hypopnoea index and angiographic 
coronary disease phenotypes in patients presenting with acute 
myocardial infarction.
MedLine Citation:
PMID:  23738622     Owner:  NLM     Status:  In-Data-Review    
Abstract Background: Relationship between obstructive sleep apnoea and atherosclerosis has not been confirmed using coronary angiography. We sought to investigate the relationships between the apnoea-hypopnoea index (AHI) and angiographic coronary disease phenotypes. 
Methods: SYNTAX score, lesion complexity, and thrombus burden grade were determined in 125 patients presenting with acute myocardial infarction and had undergone a screening sleep study. Severe OSA was defined as AHI ≥ 30.
 Results: Most of the recruited patients were male (97.6%). Severe obstructive sleep apnoea was diagnosed in 37% of the patients. The severe obstructive sleep apnoea group (n = 46) was older (P = 0.039) and more obese (P = 0.003) than the non-severe group (n = 79). There was no evidence of difference between the severe and non-severe obstructive sleep apnoea groups with regard to SYNTAX score (P = 0.871), number of complex lesions (P = 0.241), and thrombus burden grade (P = 0.433). Multivariate analysis adjusting for difference in age and body mass index did not change the findings. 
Conclusion: Using the three angiographic scoring systems, we found no association between AHI and angiographic coronary disease phenotypes, suggesting a limited effect of obstructive sleep apnoea on the amount and distribution of coronary plaques in patients presenting with acute myocardial infarction.
Thet Hein; Germaine Loo; Wai-Yee Ng; Bee-Choo Tai; Takashi Kajiya; Adeline Tan; See-Meng Khoo; Mark Chan; Adrian F Low; Boon-Lock Chia; Mark Richards; Chi-Hang Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  15     ISSN:  1748-295X     ISO Abbreviation:  Acute Card Care     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-33     Citation Subset:  IM    
National University Heart Centre Singapore, National University Health System , Singapore.
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