Document Detail

Relationship between aortic valve sclerosis and left ventricular hypertrophy in chronic haemodialysis patients.
MedLine Citation:
PMID:  18085423     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiac valve calcification is a frequent finding in chronic haemodialysis patients. Left ventricular hypertrophy (LVH) is a significant predictor of cardiovascular mortality in patients with end-stage renal disease. We evaluated the influence of aortic valve sclerosis (AVS) on the development of LVH in chronic haemodialysis patients. METHODS: A total of 82 consecutive patients (52 male, mean age 48 +/- 12 years) undergoing chronic haemodialysis treatment for > 1 year were subjected to echocardiography for the screening of AVS and the assessment of transaortic flow velocity and the left ventricular mass index (LVMI). The absence (group 1, n = 42) and presence of AVS (group 2, n = 40) was established. The average values of systolic, diastolic and pulse pressure were obtained. Plasma calcium, phosphorus, intact parathyroid hormone, C-reactive protein, haemoglobin and lipid levels were also measured. RESULTS: LVH was detected in 59 (72%) of the study patients. The LVMI was higher in the AVS group (171 +/- 39 vs. 132 +/- 41 g/m2, p < 0.001). Patients with AVS also had higher transaortic flow velocities (1.64 +/- 0.36 vs. 1.21 +/- 0.21 m/s, p < 0.01) and maximal pressure gradients (10.8 +/- 7.1 vs. 5.9 +/- 3.4 mmHg, p < 0.01). The LVMI showed a direct correlation with transaortic flow velocity in the AVS group (r = 0.60, p < 0.01). Stepwise linear regression analysis revealed transaortic flow velocity (p = 0.02), pulse pressure (p = 0.01) and haemoglobin levels (inverse relationship) (p = 0.02) to be independent predictors of the LVMI. CONCLUSION: These data suggest that AVS is strongly and independently interrelated with LVH in chronic haemodialysis patients. The underlying mechanism might be the valve resistance to left ventricular outflow, as shown by increased transaortic flow velocities and maximal pressure gradients in AVS patients.
Funda Turkmen; Ayse Emre; Ali Ozdemir; Can Sevinc; Emre Erisken; Kemal Yesilcimen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International urology and nephrology     Volume:  40     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM    
Fresenius-Diamed Hemodialysis Center, Haydarpasa Research Hospital, Istanbul, Turkey.
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MeSH Terms
Aortic Valve / pathology*
Aortic Valve Insufficiency / epidemiology
Coronary Circulation
Hypertrophy, Left Ventricular / epidemiology,  physiopathology*
Kidney Failure, Chronic / epidemiology,  pathology,  physiopathology*,  therapy
Linear Models
Middle Aged
Mitral Valve Insufficiency / epidemiology
Renal Dialysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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