Document Detail

Relationship between aortic valve calcification and the severity of coronary atherosclerotic disease.
MedLine Citation:
PMID:  20845894     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: Aortic valve calcification (AVC), which has been confirmed to be associated with various risk factors of cardiac disease, is common in the elderly and associated with increased cardiovascular mortality. It has been hypothesized that AVC is associated with coronary atherosclerotic disease, and its severity. METHODS: Between July 2007 and November 2007, a total of 235 patients with chest pain or chest distress were admitted to the authors' institution for coronary angiography. The severity of coronary atherosclerotic disease (CAD) was evaluated by the Gensini score, the number of stenosed vessels, and the prevalence of total occlusion. All patients underwent transthoracic echocardiography to detect AVC. RESULTS: Patients with CAD had a higher prevalence of AVC than those without CAD (44% versus 26%, p = 0.005). Likewise, the prevalence of AVC was significantly higher in patients with a higher Gensini score than in those with a lower score. Patients with AVC had a higher prevalence of CAD, and higher Gensini scores and numbers of stenosed coronary arteries, even after stratification by age (65 years). On multivariable logistic regression analysis for CAD, the odds ratio (OR) of AVC was 2.315 (95% confidence interval (CI): 1.158-4.629, p = 0.018); this value was higher than that for total cholesterol (OR = 1.637, p = 0.008), lipoprotein-a (OR = 1.003, p = 0.015) and fibrinogen (OR = 1.009, p = 0.006), and marginally less than that for male gender (OR = 2.665, p = 0.005). CONCLUSION: Patients with AVC had a higher prevalence and greater severity of CAD.
Juying Qian; Zhangwei Chen; Junbo Ge; Jianying Ma; Shufu Chang; Bing Fan; Xuebo Liu; Lei Ge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  19     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
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MeSH Terms
Aortic Valve* / ultrasonography
Calcinosis / epidemiology*,  ultrasonography
Chi-Square Distribution
China / epidemiology
Coronary Angiography
Coronary Stenosis / epidemiology*,  radiography
Cross-Sectional Studies
Heart Valve Diseases / epidemiology*,  ultrasonography
Logistic Models
Middle Aged
Odds Ratio
Risk Assessment
Risk Factors
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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