Document Detail

Relationship between antisperm antibodies, sperm movement, and semen quality.
MedLine Citation:
PMID:  11112869     Owner:  NLM     Status:  MEDLINE    
The presence of antisperm antibodies might impair fertilization by affecting sperm function in different ways. The aim of this study was to analyze the incidence of antisperm antibodies and evaluate its impact on sperm movement, in normozoospermic and abnormal semen samples. Samples from 144 patients were classified as normozoospermic or abnormal, according to WHO guidelines and Kruger's strict criteria. Motilility was assessed by a computer-assisted system by placing a drop of semen in a Makler chamber. Antisperm antibodies were detected using the Mar Test and Immunobead tests to identify immunoglobulin location and isotype. Results showed no association between the presence of antisperm antibodies and semen quality. Antibody incidence was 15 and 9.5% for normozoospermic and abnormal semen samples, respectively. Motion analysis showed that, although sperm linearity was significantly reduced in abnormal patients with antibodies, the existence of an immune response did not affect the sperm pathway in most cases. This study suggests that sperm motion analysis would not be of great assistance in the screening of an immunological male fertility factor.
M J Munuce; C L Berta; F Pauluzzi; A M Caille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Urologia internationalis     Volume:  65     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  200-3     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Reprolab-Sanatorio Británico de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
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MeSH Terms
Autoantibodies / analysis*
Diagnosis, Computer-Assisted
Infertility, Male / diagnosis,  immunology*
Sampling Studies
Semen / cytology,  physiology*
Sensitivity and Specificity
Sperm Motility / physiology*
Spermatozoa / immunology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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