Document Detail


Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes.
MedLine Citation:
PMID:  8989426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121-210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160-192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.
Authors:
E Grene; G Mezule; G Borisova; P Pumpens; Z Bentwich; R Arnon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  13     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-51     Citation Subset:  IM; X    
Affiliation:
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / immunology*
Adult
Amino Acid Sequence
Animals
Female
HIV Antibodies / blood
HIV Core Protein p24 / genetics,  immunology
HIV Envelope Protein gp120 / genetics,  immunology
HIV Infections / immunology
HIV-1 / immunology*
Hepatitis B Core Antigens / immunology
Hepatitis B virus* / genetics
Humans
Immunodominant Epitopes / genetics,  immunology*
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Peptide Fragments / genetics,  immunology
Rabbits
Recombinant Fusion Proteins
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/HIV Antibodies; 0/HIV Core Protein p24; 0/HIV Envelope Protein gp120; 0/HIV envelope protein gp120 (305-321); 0/Hepatitis B Core Antigens; 0/Immunodominant Epitopes; 0/Peptide Fragments; 0/Recombinant Fusion Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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