Document Detail

Relationship between the antibacterial and immunological activities of houttuyfonate homologues and their surface activities.
MedLine Citation:
PMID:  16864443     Owner:  NLM     Status:  MEDLINE    
Based on the microbial model (Staphylococcus aureus and Bacillus subtilis) and the experiment of mouse carbon granular clearance, the relationship between antibacterial and immunological activities of houttuyfonate (HOU) homologues and their surface activities were studied. The results showed that with elongating the carbon chain of HOU homologues, the surface activities and bacteriostasis and immunological activities would be increased. It is suggested that the pharmacological effect of HOU homologues could be realized by the hydrophobic interaction between HOU homologues and membrane proteins of bacteria and cell.
X-L Ye; X-G Li; L-J Yuan; H-M He
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  8     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2007-02-27     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
School of Life Science, Southwest China Normal University, Chongqing, 400715, China.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  pharmacology*
Bacillus subtilis / drug effects
Carbon / metabolism
Dose-Response Relationship, Drug
Drugs, Chinese Herbal / chemistry*,  pharmacology*
Liver / drug effects
Saururaceae / chemistry*
Spleen / drug effects
Staphylococcus aureus / drug effects
Surface-Active Agents / chemistry
Thymus Gland / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Drugs, Chinese Herbal; 0/Surface-Active Agents; 7440-44-0/Carbon

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