| Relationship between ammonia, heart rate, and exertion in McArdle's disease. | |
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MedLine Citation:
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PMID: 1539642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied plasma ammonia and exercise tolerance in six patients with McArdle's disease (myophosphorylase deficiency, type V glycogenosis) during incremental cycle ergometry. Tests were performed either in the postabsorptive state or after supplementation with branched-chain amino and 2-oxoacids and glucose. Glucose and branched-chain 2-oxoacid combined increased total work performed from control 49 +/- 22 to 80 +/- 36 kJ (P less than 0.05). Glucose alone also improved total work performed from 49 +/- 22 to 64 +/- 33 kJ (P less than 0.05). Branched-chain 2-oxoacids alone had a variable effect, and branched-chain amino acids were of no benefit. Correlations between plasma ammonia and heart rate for individual patients were r = 0.99, P less than 0.01; r = 0.95, P less than 0.01; r = 0.84, P less than 0.01; r = 0.76, P less than 0.01; r = 0.73, P less than 0.01; and r = 0.63, P less than 0.05 and between ammonia and perceived exertion for all patients combined was r = 0.70, P less than 0.0001. In two patients, correlation of ammonia with heart rate at a power output of 60 W was r = 0.91, P less than 0.001 and at 40 W was r = 0.77, P less than 0.001. We conclude that ammonia is either a mediator or a marker of the metabolic events leading to fatigue. |
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Authors:
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J H Coakley; A J Wagenmakers; R H Edwards |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-31 Completed Date: 1992-03-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E167-72 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Liverpool, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amino Acids, Branched-Chain / pharmacology* Ammonia / blood* Drug Combinations Exercise Test Female Glucose / pharmacology Glycogen Storage Disease Type V / blood, physiopathology* Heart Rate* Humans Keto Acids / pharmacology Leucine / pharmacology Male Middle Aged Osmolar Concentration Physical Endurance / drug effects Physical Exertion* Valine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain; 0/Drug Combinations; 0/Keto Acids; 50-99-7/Glucose; 61-90-5/Leucine; 7004-03-7/Valine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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