| Relationship between ambulatory blood pressure and aortic arch atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 22296886 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. METHODS: The study population consisted of 795 patients (mean age 71±9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. RESULTS: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥4mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95% CI 1.00-1.93, P<0.05). CONCLUSION: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression. |
| | |
Authors:
|
Shinichi Iwata; Zhezhen Jin; Joseph E Schwartz; Shunichi Homma; Mitchell S V Elkind; Tatjana Rundek; Ralph L Sacco; Marco R Di Tullio |
Related Documents
:
|
3611776 - Posture- and emotion-induced severe hypertensive paroxysms with baroreceptor dysfunction. 12024956 - Effect of 60 degrees head-up tilt on systolic time intervals in hypertensive patients. 21744056 - Glucocorticoid-induced hypertension. 15834766 - Does peripheral nerve degeneration affect circulatory responses to head-up tilt in spin... 1887746 - Effects of glycopyrrolate and atropine on heart rate variability. 10896376 - The influence of 2 surgical bandage systems on wound tissue oxygen tension. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Medicine, Columbia University, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in pati...
Next Document: Comparison of in vitro and in vivo systems to study ica-independent Staphylococcus aureus biofilms.