| Relationship between ambulatory blood pressure and aortic arch atherosclerosis. | |
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MedLine Citation:
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PMID: 22296886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. METHODS: The study population consisted of 795 patients (mean age 71 ± 9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. RESULTS: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥ 4 mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95% CI 1.00-1.93, P<0.05). CONCLUSION: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression. |
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Authors:
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Shinichi Iwata; Zhezhen Jin; Joseph E Schwartz; Shunichi Homma; Mitchell S V Elkind; Tatjana Rundek; Ralph L Sacco; Marco R Di Tullio |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-01-10 |
Journal Detail:
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Title: Atherosclerosis Volume: 221 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-26 Completed Date: 2012-07-26 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 427-31 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Columbia University, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aorta, Thoracic / physiopathology*, ultrasonography Aortic Diseases / etiology, physiopathology*, ultrasonography Atherosclerosis / etiology, physiopathology*, ultrasonography Blood Pressure* Blood Pressure Monitoring, Ambulatory* Circadian Rhythm Cross-Sectional Studies Disease Progression Female Humans Logistic Models Male Middle Aged Multivariate Analysis New York City Odds Ratio Predictive Value of Tests Risk Assessment Risk Factors Severity of Illness Index Stroke / etiology, physiopathology Systole |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS029993/NS/NINDS NIH HHS; R01 NS029993-15/NS/NINDS NIH HHS; R01 NS036286-10/NS/NINDS NIH HHS; R01 NS36286/NS/NINDS NIH HHS |
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