| Relationship between alterations in atrial and ventricular histamine content and cardiac function during cardiac anaphylaxis of isolated guinea pig hearts. | |
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MedLine Citation:
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PMID: 1693913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antigen-induced histamine release from sensitized cardiac tissue has been shown to contribute significantly to the increases in atrial rate, atrioventricular nodal conduction, and ventricular contractile force that occur during cardiac anaphylaxis. These findings suggest that there might be a strong negative correlation between changes in these variables and the residual histamine content in the tissue after the anaphylactic reaction. In the present study using isolated hearts of passively sensitized guinea pigs, antigen challenge evoked transient increases in atrial automaticity, P-R intervals, vascular resistance, and left ventricular pressure. The histamine content of atrial and ventricular tissue from antigen-challenge hearts (1,475 +/- 296 and 4,543 +/- 360 ng/g, respectively) was significantly less than that of nonchallenged hearts (2,652 +/- 335 and 6,298 +/- 251 ng/g, respectively). Significant correlations found were between the residual histamine content of the ventricular tissue or the total histamine released and the magnitude of the antigen-induced increase in left ventricular systolic pressure. These findings suggest that antigen-induced increases in left ventricular systolic pressure can be used as an index of the local ventricular histamine release. The lack of significant correlations between local residual histamine levels and changes in atrial rate, P-R intervals, or coronary vascular resistance suggests that complicated interactions between histamine and other mediators or factors may be involved in the antigen-induced chronotropic, dromotropic, and vasoconstrictive alterations in these preparations. |
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Authors:
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L J Heller; J E Regal |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International archives of allergy and applied immunology Volume: 91 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-07-24 Completed Date: 1990-07-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 285-90 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Minnesota, Duluth School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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metabolism*,
physiopathology Animals Blood Pressure Guinea Pigs Heart Atria / analysis, secretion Heart Diseases / metabolism*, physiopathology Heart Ventricles / analysis, secretion Histamine / analysis Histamine Release* Myocardium / analysis*, metabolism Organ Size |
| Grant Support | |
ID/Acronym/Agency:
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HL-34351/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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