Document Detail


Relationship between the airway wall area and asthma control score in moderate persistent asthma.
MedLine Citation:
PMID:  23300036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess the association between airway wall area and clinical asthma control, assessed by the Asthma Control Test (ACT).
METHODS: This cross-sectional study evaluated 96 adults for asthma control ["at least well controlled" (ACT ≥ 20; n = 52) or "not well controlled" (ACT < 20; n = 44) and airway dimensions: luminal area (LA), wall area (WA) and WA%], obtained using automated dedicated software measurements from volumetric CT images. Results were analysed for segmental bronchi, subsegmental bronchi in the right upper lobe and basilar segments, both uncorrected and corrected for body surface area (BSA).
RESULTS: For all bronchi corrected for BSA, there was no correlation between airway wall area and ACT score. There was a weak but statistically significant correlation between uncorrected WA and ACT score (r = -0.203; P = 0.047); WA values were numerically higher in the "not well-controlled" versus the "at least well-controlled asthma" subgroups. For sub-segmental bronchi, there was a correlation between the ACT score and both WA/BSA (r = -0.204; P = 0.047) and WA (r = -0.249; P = 0.014), and for upper lobe bronchi, between the ACT score and WA (r = -0.207; P = 0.044).
CONCLUSION: We demonstrated a correlation between subsegmental bronchial airway measurements and clinical control of asthma; this is probably a reflection of airway remodelling and structural changes in chronic poorly controlled asthma.
KEY POINTS: • Volumetric computed tomography offers new insights into bronchial morphology. • The relationship between current asthma control and airway wall abnormalities is assessed. • Some relationships between airway wall area and clinical control were demonstrated. • We observed less shape variation of bronchi in "not well-controlled" asthma patients.
Authors:
Pierre-Yves Brillet; Philippe A Grenier; Catalin I Fetita; Catherine Beigelman-Aubry; Yahya Ould-Hmeidi; Margarete Ortner; Gaëlle Nachbaur; Lukasz Adamek; Pascal Chanez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  European radiology     Volume:  23     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-12-26     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1594-602     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Remodeling*
Asthma / diagnosis*,  pathology,  therapy*
Body Surface Area
Bronchi / pathology*
Bronchography / methods*
Cross-Sectional Studies
Female
Forced Expiratory Volume
Humans
Lung / radiography
Male
Middle Aged
Software
Tomography, X-Ray Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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