Document Detail


Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender.
MedLine Citation:
PMID:  8126124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether gender affects the physiological relationships between the release of GH and age, body composition, and levels of physical fitness in humans. We studied 32 eumenorrheic females (age = 31 +/- 5 yr) and 12 males (age = 27 +/- 5 yr). Significant gender differences were found for peak oxygen consumption [VO2 peak = 40.5 +/- 6.9 (females) vs. 50.1 +/- 11.6 (males) ml/kg.min-1, P < 0.05] and body composition [hydrostatic weighing, percentage body fat = 28.7 +/- 5.4 (females) vs. 18.1 +/- 9.8 (males), P < 0.05] but not for body mass index [BMI = 23.7 +/- 3.1 (females) vs. 24.0 +/- 3.3 (males)]. Blood samples were drawn every 10 min for 24 h from 0800 h to determine integrated serum GH concentration [2350 +/- 1260 (females) vs. 3110 +/- 1760 (males) microgram/L x min]; females were studied during the early follicular phase (days 4-5) of the menstrual cycle. In females, a significant relationship existed between 24-h integrated serum GH concentration and age (r = -0.35, P = 0.05) but not BMI (r = -0.19, P = 0.29); the relationship between 24-h integrated serum GH concentration and VO2 peak (r = 0.31, P = 0.08) and percentage body fat (r = 0.29, P = 0.11) approached significance. In males, significant relationships existed between 24-h integrated serum GH concentration and age (r = -0.79, P = 0.002), percentage body fat (r = -0.75, P = 0.005), and VO2 peak (r = 0.58, P = 0.05) but not between 24-h integrated serum GH concentration and BMI (r = -0.53, P = 0.08). Standardized regression coefficients revealed that for each SD change in age, BMI, percentage body fat, or VO2 peak the associated change in 24-h integrated serum GH concentration was 1.9-2.6 times greater in males than in females. We conclude that age, percentage body fat (but not BMI), and fitness are related to 24-h GH release in young adults and that these relationships are considerably stronger in males than females.
Authors:
A Weltman; J Y Weltman; M L Hartman; R D Abbott; A D Rogol; W S Evans; J D Veldhuis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  78     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-12     Completed Date:  1994-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-8     Citation Subset:  AIM; IM    
Affiliation:
Exercise Physiology Laboratory, Curry School of Education, University of Virginia, Charlottesville 22903.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Adult
Aging / metabolism*
Body Composition*
Body Mass Index
Circadian Rhythm*
Female
Growth Hormone / metabolism*
Humans
Male
Physical Fitness*
Reference Values
Sex Characteristics*
Grant Support
ID/Acronym/Agency:
HD-00634/HD/NICHD NIH HHS; R01 AG10997/AG/NIA NIH HHS; R01 HD-20465/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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