| Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome. | |
| | |
MedLine Citation:
|
PMID: 16538006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP (hs-CRP) and intercellular adhesion molecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI> or = 40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1 were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1 were significantly higher in the IHD(AHI > or = 40) group than in the IHD(AHI<40) group (p<0.01). However, after the administration of valsartan, angiotensin II receptor antagonists (ARB) to both IHD groups, the levels of hs-CRP and ICAM-1 decreased significantly in both groups. Moreover, a multivariate analysis revealed that the levels of hs-CRP and ICAM-1 were associated with the severity of sleep apnea. These findings suggest that, in OSAS the levels of hs-CRP and ICAM-1 are decreased and that the administration of ARB decreases the risk of atherosclerosis. |
| | |
Authors:
|
Norihito Kageyama; Masahiro Nomura; Yutaka Nakaya; Tomonori Watanabe; Susumu Ito |
Related Documents
:
|
9443766 - Sleep related breathing disorders are common contributing factors to the production of ... 17664676 - An efficient method for snore/nonsnore classification of sleep sounds. 11888956 - Home unattended vs hospital telemonitored polysomnography in suspected obstructive slee... 19436316 - Dynamic changes in brain bioenergetics during obstructive sleep apnea. 3537416 - Mood alterations and sleep. 10084626 - Visual functions of drivers involved in traffic accidents. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The journal of medical investigation : JMI Volume: 53 ISSN: 1343-1420 ISO Abbreviation: J. Med. Invest. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-03-15 Completed Date: 2006-05-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9716841 Medline TA: J Med Invest Country: Japan |
Other Details:
|
Languages: eng Pagination: 134-9 Citation Subset: IM |
Affiliation:
|
Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Arteriosclerosis / etiology, prevention & control C-Reactive Protein / metabolism Case-Control Studies Female Humans Intercellular Adhesion Molecule-1 / blood Interleukin-6 / blood Male Middle Aged Myocardial Ischemia / blood, complications, drug therapy Sleep Apnea, Obstructive / blood, complications, drug therapy* Tetrazoles / therapeutic use* Valine / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Interleukin-6; 0/Tetrazoles; 126547-89-5/Intercellular Adhesion Molecule-1; 137862-53-4/valsartan; 7004-03-7/Valine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguan...
Next Document: Effect of saliva collection method on the concentration of protein components in saliva.