Document Detail

Relationship between acute physiologic derangement and risk of death.
MedLine Citation:
PMID:  3998046     Owner:  NLM     Status:  MEDLINE    
Initial evidence from 481 acutely ill patients with 12 major life-threatening diseases suggests a consistent relationship between the magnitude of physiologic derangement and the patient's risk of death. These results were found in postoperative and nonoperative diseases, including gastrointestinal bleeding, intracranial bleeding, pneumonia, congestive heart failure, trauma and hemorrhagic shock. There appear to be substantial differences in the inherent risk of these diseases, but within each diagnosis, the impact of incremental increases in physiologic derangement on mortality appears to be similar. The existence of a uniform relationship in a variety of diagnoses could have important implications for the researcher and clinician wishing to evaluate outcome from intense medical care. It would allow more reproducible and precise stratification of patients by risk of death prior to therapy, thereby improving our understanding of the efficacy of new and existing treatments.
W A Knaus; D P Wagner; E A Draper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of chronic diseases     Volume:  38     ISSN:  0021-9681     ISO Abbreviation:  J Chronic Dis     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-08     Completed Date:  1985-07-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985123R     Medline TA:  J Chronic Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
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MeSH Terms
Heart Failure / mortality
Hemorrhage / mortality
Intensive Care Units
Pneumonia / mortality
Postoperative Complications / mortality
Shock / mortality
Wounds and Injuries / mortality
Grant Support

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