Document Detail


The relationship between vitamin D status and HIV-related complications in HIV-infected children and young adults.
MedLine Citation:
PMID:  23360833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In HIV-infected adults, we and others have shown that vitamin D deficiency is independently associated with increased carotid intima-media thickness (cIMT), a surrogate marker for cardiovascular disease (CVD). This study explored for the first time the relationship between vitamin D and CVD risk in HIV-infected youth.
METHODS: This is a cross-sectional assessment of cIMT, inflammation, metabolic markers and vitamin D status in HIV-infected youth and healthy controls. We measured serum 25-hydroxyvitamin D (25(OH)D), fasting lipids, insulin, glucose, inflammatory markers and cIMT.
RESULTS: Thirty HIV-infected subjects and 31 controls were included. Among HIV-infected subjects, median age was 11 years (37% males; 73% black; similar to controls). HIV-infected subjects' mean (standard deviation) serum 25(OH)D was 24 (35) ng/mL; 70% had 25(OH)D<20 ng/mL (deficient), 23% between 20-30 ng/mL (insufficient) and 7%>30 ng/mL (sufficient); proportions were similar to controls (P=0.17). After adjusting for season, sex and race, there was no difference in serum 25(OH)D between groups (P=0.11). Serum 25(OH)D was not significantly correlated with cIMT, inflammatory markers or lipids. Serum 25(OH)D was negatively correlated with body mass index, insulin resistance, HIV duration, and cumulative use of antiretroviral therapy, non- and nucleoside reverse transcriptase inhibitors.
CONCLUSIONS: Most HIV-infected youth have vitamin D deficiency or insufficiency. Despite no direct association between serum 25(OH)D and cIMT, there were notable associations with some CVD risk factors, particularly inverse correlation with insulin resistance. Studies are needed to determine whether CVD risk, including insulin resistance, could be improved with vitamin D supplementation.
Authors:
Allison Ross Eckard; Vin Tangpricha; Shabnam Seydafkan; Mary Ann O'Riordan; Norma Storer; Danielle Labbato; Grace A McComsey
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Publication Detail:
Type:  Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  32     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-21     Completed Date:  2014-06-13     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cardiovascular Diseases / blood,  virology
Carotid Intima-Media Thickness
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Female
HIV Infections / blood*,  pathology*
Humans
Insulin Resistance
Longitudinal Studies
Male
Risk Factors
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / blood*,  pathology,  virology*
Young Adult
Grant Support
ID/Acronym/Agency:
1K23HD069199/HD/NICHD NIH HHS; K23 HD069199/HD/NICHD NIH HHS; P30 AI036219/AI/NIAID NIH HHS; R01 AI065348/AI/NIAID NIH HHS; R01 HD070490/HD/NICHD NIH HHS; R01HD070490/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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