Document Detail


Relationship between Venous and Arterial Thrombosis: A Review of the Literature from a Causal Perspective.
MedLine Citation:
PMID:  22198853     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Venous thrombosis and arterial thrombosis are traditionally regarded as two different diseases with respect to pathophysiology, epidemiology, and treatment strategies. Research findings of the past few years suggest that this categorical distinction may be too strict. However, whether the described relationship between venous and arterial thrombosis is real or a result of other factors such as confounding, chance, or bias is still unclear. In this review, we discuss the current literature while using causal diagrams to better understand possible causal relations between cardiovascular risk factors, atherosclerosis, arterial thrombosis, and venous thrombosis. Furthermore, we propose study designs to investigate the causal link between venous and arterial thrombosis. In addition, we comment on the effect of statin use on the occurrence of both arterial and venous thrombosis. The possible clinical implications of these findings are discussed.
Authors:
Willem M Lijfering; Linda E Flinterman; Jan P Vandenbroucke; Frits R Rosendaal; Suzanne C Cannegieter
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Publication Detail:
Type:  Journal Article     Date:  2011-12-23
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  37     ISSN:  1098-9064     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-96     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Affiliation:
Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands.
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