Document Detail

Relationship between Structure and Antiproliferative Activity of Polymethoxyflavones towards HL60 Cells.
MedLine Citation:
PMID:  23225422     Owner:  NLM     Status:  In-Data-Review    
As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure-activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3'-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3'-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs.
Satoru Kawaii; Tomoyasu Ikuina; Takeshi Hikima; Tetsuo Tokiwano; Yuko Yoshizawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5239-44     Citation Subset:  IM    
Faculty of Science and Engineering, Tokyo Denki University, Hatoyama, Saitama, 350-0394, Japan.
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