Document Detail


The relationship between serum adiponectin levels with the presence and severity of coronary artery disease.
MedLine Citation:
PMID:  23020536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adiponectin plays important roles in the endocrine and cardiovascular systems, in fat and carbohydrate metabolism, and inflammation. In this study the relationship between adiponectin levels with the presence and severity of coronary artery disease (CAD) is evaluated.
METHODS: This was a cross-sectional study that enrolled 213 persons who referred for coronary angiography. One cardiologist reported the results of each coronary angiography by using two scoring systems [number of vessel disease (usual method) and Gensini scoring system]. Then, the relationship between adiponectin levels with the presence and severity of CAD as well as predictive factors for CAD were evaluated.
RESULTS: There was a significant negative association between mean serum adiponectin levels and presence of CAD (P = 0.04) after adjustment for all conventional risk factors for CAD. Also there was a significant negative correlation between serum adiponectin levels and severity of CAD based on the usual method for reporting coronary angiograms (P = 0.01). After adjustment for all conventional risk factors for CAD the serum adiponectin level tended to be inversely associated with the Gensini score (P = 0.09). Logistic regression analysis showed that a higher serum adiponectin level was negatively and independently associated with CAD (odds ratio: 0.94; 95% confidence interval: 0.88-1.00; P < 0.05). The variables predictive of serum adiponectin levels were determined as follows: HDL-cholesterol (P = 0.001); age (P = 0.002); insulin resistance (P = 0.005) and triglycerides (P = 0.036). 
CONCLUSIONS: This cross-sectional study showed a significant negative association between serum adiponectin levels to the presence and severity of CAD.
Authors:
Mesbah Shams; Akbar Rasekhi Kazerouni; Mohammad Ali Ostovan; Gholamhossein Ranjbar Omrani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-04     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  611-6     Citation Subset:  IM    
Affiliation:
Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Biological Markers / blood
Cardiovascular Diseases / blood*,  radiography
Coronary Angiography
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers

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