| The relationship between serum adiponectin levels with the presence and severity of coronary artery disease. | |
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MedLine Citation:
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PMID: 23020536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin plays important roles in the endocrine and cardiovascular systems, in fat and carbohydrate metabolism, and inflammation. In this study the relationship between adiponectin levels with the presence and severity of coronary artery disease (CAD) is evaluated. METHODS: This was a cross-sectional study that enrolled 213 persons who referred for coronary angiography. One cardiologist reported the results of each coronary angiography by using two scoring systems [number of vessel disease (usual method) and Gensini scoring system]. Then, the relationship between adiponectin levels with the presence and severity of CAD as well as predictive factors for CAD were evaluated. RESULTS: There was a significant negative association between mean serum adiponectin levels and presence of CAD (P = 0.04) after adjustment for all conventional risk factors for CAD. Also there was a significant negative correlation between serum adiponectin levels and severity of CAD based on the usual method for reporting coronary angiograms (P = 0.01). After adjustment for all conventional risk factors for CAD the serum adiponectin level tended to be inversely associated with the Gensini score (P = 0.09). Logistic regression analysis showed that a higher serum adiponectin level was negatively and independently associated with CAD (odds ratio: 0.94; 95% confidence interval: 0.88-1.00; P < 0.05). The variables predictive of serum adiponectin levels were determined as follows: HDL-cholesterol (P = 0.001); age (P = 0.002); insulin resistance (P = 0.005) and triglycerides (P = 0.036). CONCLUSIONS: This cross-sectional study showed a significant negative association between serum adiponectin levels to the presence and severity of CAD. |
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Authors:
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Mesbah Shams; Akbar Rasekhi Kazerouni; Mohammad Ali Ostovan; Gholamhossein Ranjbar Omrani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of Iranian medicine Volume: 15 ISSN: 1735-3947 ISO Abbreviation: Arch Iran Med Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2013-02-04 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 100889644 Medline TA: Arch Iran Med Country: Iran |
Other Details:
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Languages: eng Pagination: 611-6 Citation Subset: IM |
Affiliation:
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Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Biological Markers / blood Cardiovascular Diseases / blood*, radiography Coronary Angiography Cross-Sectional Studies Female Humans Male Middle Aged Predictive Value of Tests Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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