Document Detail

Relationship between REM sleep latency and nocturnal cortisol concentrations in depressed patients.
MedLine Citation:
PMID:  10607027     Owner:  NLM     Status:  Publisher    
Due to conflicting reports on the possible association between shortening of rapid eye movement (REM) latency and increased cortisol secretion in patients with severe depression, this study examined the relationship between REM sleep latency and nocturnal cortisol concentration in 12 outpatients with major depression. The results showed a significant inverse correlation (r = -0.71, P < 0.01) between REM sleep latency and mean (23.00 hours-03.00 hours) plasma cortisol concentration. Age and severity of depression did not contribute to the inverse relationship. REM activity and density during the first REM period showed no significant correlations with the cortisol measures. A review of the literature suggests that this relationship might be unique to subjects with major depression, and again raises the possibility that these biological disruptions may have a common neurochemical basis.
Poland; McCracken; Lutchmansingh; Tondo
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Publication Detail:
Journal Detail:
Title:  Journal of sleep research     Volume:  1     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1999-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  54-57     Citation Subset:  -    
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA.
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