Document Detail

Relationship between Primary Nodal Generalized Osteoarthritis with Tissue Antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey.
MedLine Citation:
PMID:  21422676     Owner:  NLM     Status:  In-Data-Review    
Objective To investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey. Patients and Methods Forty-six patients with NGOA (64.74±8.46) and 60 controls (62.32±6.8) were included in the study. Inclusion criteria were: (i) stage 2 and higher OA of the hand and knee based on the Kellgren-Lawrence classification, and (ii) stage 2 and higher lumbar disc degeneration according to Lawrence classification. Family histories were taken from patients. HLA-A and HLA-B were typed by PCR using sequence specific primer. Results The frequencies of HLA-A(*)02 and HLA-B(*)38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A(*)02 and HLA-B(*)38. The relationship between positive family history and HLA-B(*)44 allele was also statistically significant. In the control group, the frequency of HLA-A(*)29 was 11.7% and it was statistically significant. Conclusion To our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A(*)02 and HLA-B(*)38 with NGOA in our population. We conclude that, HLA-B(*)44 positivity may be associated with familial NGOA and HLA-A(*)29 may be a preventive factor against NGOA.
Cemal Tasligil; Sirzat Cogalgil; Esra Tug; Burak Tonuk; Ozlem Sahin; Dilek Dogruer
Related Documents :
8814046 - Patients' perceptions compared with objective ratings of asthma severity.
6625226 - Relation between positive small air ions, weather fronts and pulmonary function in pati...
6219556 - A study of t suppressor activity after bacterial immunotherapy.
19479666 - Reslizumab, a humanized anti-il-5 mab for the treatment of eosinophil-mediated inflamma...
23039206 - Serum ifn-λ1 is abnormally elevated in rheumatoid arthritis patients.
930946 - Effects of corticosteroids in the treatment of patients with gastric aspiration.
Publication Detail:
Type:  Journal Article     Date:  2011-03-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  50     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Department of Physican Medicine and Rehabilitation, Abant Izzet Baysal University, Izzet Baysal Medical School, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gastric Mucosal Damage Evaluated by Transnasal Endoscopy and QOL Assessments in Ischemic Heart Disea...
Next Document:  Ratio of urinary potassium to urinary sodium and the potassium and edema status in nephrotic syndrom...