| Relationship between Primary Nodal Generalized Osteoarthritis with Tissue Antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey. | |
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MedLine Citation:
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PMID: 21422676 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective To investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey. Patients and Methods Forty-six patients with NGOA (64.74±8.46) and 60 controls (62.32±6.8) were included in the study. Inclusion criteria were: (i) stage 2 and higher OA of the hand and knee based on the Kellgren-Lawrence classification, and (ii) stage 2 and higher lumbar disc degeneration according to Lawrence classification. Family histories were taken from patients. HLA-A and HLA-B were typed by PCR using sequence specific primer. Results The frequencies of HLA-A(*)02 and HLA-B(*)38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A(*)02 and HLA-B(*)38. The relationship between positive family history and HLA-B(*)44 allele was also statistically significant. In the control group, the frequency of HLA-A(*)29 was 11.7% and it was statistically significant. Conclusion To our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A(*)02 and HLA-B(*)38 with NGOA in our population. We conclude that, HLA-B(*)44 positivity may be associated with familial NGOA and HLA-A(*)29 may be a preventive factor against NGOA. |
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Authors:
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Cemal Tasligil; Sirzat Cogalgil; Esra Tug; Burak Tonuk; Ozlem Sahin; Dilek Dogruer |
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Publication Detail:
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Type: Journal Article Date: 2011-03-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 50 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 545-50 Citation Subset: IM |
Affiliation:
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Department of Physican Medicine and Rehabilitation, Abant Izzet Baysal University, Izzet Baysal Medical School, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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