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The Relationship between Normal Cerebral Perfusion Patterns and White Matter Lesion Distribution in 1,249 Patients with Multiple Sclerosis.
MedLine Citation:
PMID:  21447022     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: The pathological differences underlying the clinical disease phases in multiple sclerosis (MS) are poorly characterized. We sought to explore the relationship between the distribution of white matter (WM) lesions in relapsing-remitting (RR) and secondary progressive (SP) MS and the normal regional variability of cerebral perfusion. METHODS: WM lesions were identified and quantified on a single magnetic resonance imaging scan from 1,249 patients with MS. The spatial distribution of lesions was compared between early RR, late RR, and SP MS in the context of normal cerebral perfusion patterns provided by a single-photon emission-computed tomography atlas of healthy individuals. RESULTS: Patients with SP MS had more distinct and larger lesions than patients with RR MS. Across all subjects, lesions were present in regions of relatively lower normal perfusion than normal appearing WM. Further, lesions in SP MS were more common in areas of lower perfusion as compared to the lesion distribution in early and late RR MS. CONCLUSION: Chronic plaques were more prevalent in WM regions with lower relative perfusion. Lesions in more highly perfused regions were more commonly observed in early RR MS and therefore, may be more likely to successfully remyelinate and resolve.
Christopher M Holland; Arnaud Charil; Istvan Csapo; Zsuzsanna Liptak; Masanori Ichise; Samia J Khoury; Rohit Bakshi; Howard L Weiner; Charles R G Guttmann
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-29
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  -     ISSN:  1552-6569     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 by the American Society of Neuroimaging.
Center for Neurological Imaging and Partners MS Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CMH, IC, ZL, SJK, RB, HLW, CRGG); Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA (CMH); Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada (AC); Brain Molecular Imaging Program, Division of Nuclear Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (MI).
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