| Relationship between N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and cardiac cycle efficiency in cardiac surgery. | |
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MedLine Citation:
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PMID: 20137881 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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N-terminal pro-B-type natriuretic peptide (Nt-proBNP) is a peptide released from myocardium in response to ventricular wall stress and dysfunction. Nt-proBNP plasma levels are elevated in a variety of cardiovascular disorders and are largely used for diagnosis and treatment of cardiac diseases. The cardiac cycle efficiency (CCE) is a haemodynamic variable that represents the left ventricle wall stress and the heart's effort to maintain an adequate blood flow to tissues. We investigated the relationship between Nt-proBNP and CCE values in patients undergoing cardiac surgery. Twenty-five patients undergoing aortic valve replacement were studied. Plasma Nt-proBNP concentrations were performed by electroluminescence immunoassay before starting surgery (t0), at the end of extracorporeal circulation (t1) and 3 hours after surgery (t2). CCE measurements were acquired at the same intervals and correlations with Nt-proBNP levels were calculated. Nt-proBNP plasma concentration was 1430 ± 341 pg/ml at t0, peaked significantly at t1 (2129 ± 561 pg/ml, p<0.001) and moderately decreased at t2 (1924 ± 477 pg/ml, p<0.05). A direct correlation between Nt-proBNP measured at t0 and t1 was found (r=0.91, p<0.001). Overall, a negative correlation between CCE and proBNP values was found (r=-0.89, p<0.01). Correlations between CCE and Nt-proBNP were -0.91, -0.83 and -0.88, at t0, t1 and t2, respectively (p<0.01). Nt-proBNP levels reflect the severity of left ventricle dysfunction in patients undergoing cardiac surgery. CCE correlated well with serum Nt-proBNP levels and seems to be a useful variable to monitor the left ventricular stress and recovery during the various phases of surgery. |
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Authors:
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S Scolletta; G Ranaldi; F Carlucci; F Franchi; S M Romano; B Biagioli |
Publication Detail:
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Type: Journal Article Date: 2010-01-19 |
Journal Detail:
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Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Volume: 64 ISSN: 1950-6007 ISO Abbreviation: Biomed. Pharmacother. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8213295 Medline TA: Biomed Pharmacother Country: France |
Other Details:
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Languages: eng Pagination: 511-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Unit of Cardiothoracic Anaesthesia and Intensive Care, Department of Surgery and Bioengineering, University of Siena, Viale Bracci 1, 53100, Siena, Italy. scolletta@unisi.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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