| Relationship between Leg Muscle Capillary Density and Peak Hyperemic Blood Flow with Endurance Capacity in Peripheral Artery Disease. | |
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MedLine Citation:
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PMID: 21512146 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: The aim of this study was to determine if skeletal muscle capillary density is lower in patients with peripheral artery disease (PAD) and if capillary density relates to functional limitations. Background: PAD patients with intermittent claudication (IC) have a decreased exercise tolerance due to exercise induced muscle ischemia. In spite of the apparent role diminished arterial flow has in this population, the degree of walking pain and functional limitation is not entirely explained by altered hemodynamics of the affected limbs. We hypothesized that skeletal muscle capillary density is lower in PAD and is related to the functional impairment observed in this population. Methods: Sixty-four patients with PAD and 56 controls underwent cardiopulmonary exercise testing and a gastrocnemius muscle biopsy. A sub-set of these patients (48 PAD and 47 controls) underwent peak hyperemic flow testing via plethysmography. Results: Capillary density in PAD patients was lower compared with controls (p<0.001). After adjustment for several baseline demographic imbalances the model relating capillary density to peak VO2 remained significant (p<0.001). In PAD subjects, capillary density correlated with peak VO2, peak walking time (PWT), and claudication onset time (COT). Peak hyperemic blood flow related to peak VO2 in both PAD and control subjects. Conclusions: PAD is associated with lower capillary density, and capillary density is related to the functional impairment as defined by a reduced peak VO2, PWT and COT. These findings suggest that alterations in microcirculation may contribute to functional impairment capacity in PAD. |
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Authors:
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Jennifer L Robbins; W Schuyler Jones; Brian D Duscha; Jason David Allen; William E Kraus; Judith G Regensteiner; William R Hiatt; Brian H Annex |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Duke University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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