Document Detail

Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease.
MedLine Citation:
PMID:  21512146     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine if skeletal muscle capillary density is lower in patients with peripheral artery disease (PAD) and if capillary density relates to functional limitations. PAD patients with intermittent claudication (IC) have a decreased exercise tolerance due to exercise-induced muscle ischemia. Despite the apparent role diminished arterial flow has in this population, the degree of walking pain and functional limitation is not entirely explained by altered hemodynamics of the affected limbs. We hypothesized that skeletal muscle capillary density is lower in PAD and is related to the functional impairment observed in this population. Sixty-four patients with PAD and 56 controls underwent cardiopulmonary exercise testing and a gastrocnemius muscle biopsy. A subset of these patients (48 PAD and 47 controls) underwent peak hyperemic flow testing via plethysmography. Capillary density in PAD patients was lower compared with controls (P < 0.001). After adjustment for several baseline demographic imbalances the model relating capillary density to peak oxygen consumption (Vo(2)) remained significant (P < 0.001). In PAD subjects, capillary density correlated with peak Vo(2), peak walking time (PWT), and claudication onset time (COT). Peak hyperemic blood flow related to peak Vo(2) in both PAD and control subjects. PAD is associated with lower capillary density, and capillary density is related to the functional impairment as defined by a reduced peak Vo(2), PWT, and COT. These findings suggest that alterations in microcirculation may contribute to functional impairment capacity in PAD.
Jennifer L Robbins; W Schuyler Jones; Brian D Duscha; Jason D Allen; William E Kraus; Judith G Regensteiner; William R Hiatt; Brian H Annex
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-21
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  111     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2013-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, Duke University Medical Center, Box 3126, Durham, NC 27710, USA.
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MeSH Terms
Ankle Brachial Index
Capillaries / physiopathology*
Case-Control Studies
Exercise Test
Hyperemia / physiopathology*
Intermittent Claudication / diagnosis,  etiology,  physiopathology*
Lower Extremity / blood supply*
Middle Aged
Oxygen Consumption
Peripheral Arterial Disease / complications,  diagnosis,  physiopathology*
Physical Endurance*
Regional Blood Flow
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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