| Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries. | |
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MedLine Citation:
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PMID: 19593124 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To highlight clinical trials that have employed coronary artery imaging to evaluate the impact of medical therapies that target established cardiovascular risk factors. RECENT FINDINGS: High resolution imaging of the entire vessel wall permits assessment of changes in the full extent of coronary atherosclerosis. Intensive lowering of LDL cholesterol and systolic blood pressure are associated with the greatest benefit in terms of slowing disease progression. Therapeutic approaches that promote the biological activity of HDL have the potential to promote regression of atherosclerotic plaque. Targeting inflammatory cascades may also have a beneficial effect on the extent and composition of coronary plaque. SUMMARY: Intensive modification of established risk factors has a profound impact on the natural history of atheroma progression. |
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Authors:
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Stephen J Nicholls |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in lipidology Volume: 20 ISSN: 1473-6535 ISO Abbreviation: Curr. Opin. Lipidol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: England |
Other Details:
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Languages: eng Pagination: 491-6 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. nichols1@ccf.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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