Document Detail

Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries.
MedLine Citation:
PMID:  19593124     Owner:  NLM     Status:  In-Process    
PURPOSE OF REVIEW: To highlight clinical trials that have employed coronary artery imaging to evaluate the impact of medical therapies that target established cardiovascular risk factors. RECENT FINDINGS: High resolution imaging of the entire vessel wall permits assessment of changes in the full extent of coronary atherosclerosis. Intensive lowering of LDL cholesterol and systolic blood pressure are associated with the greatest benefit in terms of slowing disease progression. Therapeutic approaches that promote the biological activity of HDL have the potential to promote regression of atherosclerotic plaque. Targeting inflammatory cascades may also have a beneficial effect on the extent and composition of coronary plaque. SUMMARY: Intensive modification of established risk factors has a profound impact on the natural history of atheroma progression.
Stephen J Nicholls
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  20     ISSN:  1473-6535     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
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