Document Detail

Relationship between Incidence of Fracture and Health Related Quality of Life in Metastatic Breast Cancer Patients with Bone Metastases.
MedLine Citation:
PMID:  23043593     Owner:  NLM     Status:  Publisher    
Abstract Objective: In this retrospective observational study, we describe treatment patterns and longitudinal health related quality of life (HRQOL) among metastatic breast cancer patients with bone metastasis from 9 community oncology clinics. Methods: For description of treatment patterns, patients were classified as treated if they started zoledronic acid within 60 days of diagnosis of bone metastasis, were considered untreated if they had not, and were considered unclassified if they died or experienced fracture before 60 days had elapsed. Medical record review provided demographic and disease characteristics as well as history of treatment. Patients completed Patient Care Monitor (PCM) assessments of patient reported outcomes during routine care for up to two years from the date of bone metastasis diagnosis. Results: The overall rate of fracture in the sample was 17.4%. Of 321 patients enrolled, 160 were treated as of 60 days after diagnosis of bone metastasis, 147 were untreated, and 14 were unclassified. Of 147 untreated as of 60 days, 82 did eventually receive zoledronic acid. More than half of all patients treated with zoledronic acid delayed start of treatment more than 30 days after diagnosis of bone metastasis. Patients who had a fracture showed decreased mobility and increased pain and anxiety at fracture with recovery taking about 16 months. Limitations: Key limitations included: convenience sample with information limited to medical record content, low rate of observed fractures possibly due to limited 2 year follow up, and exclusion of non-zoledronic acid bisphosphonate use. Conclusions: Whereas the proportion of patients experiencing a fracture was small, the impact of fracture on HRQOL was significant and was more prominently seen to impact specific dimensions of HRQOL.
Mark S Walker; Paul J E Miller; Madhav Namjoshi; Arthur C Houts; Edward J Stepanski; Lee S Schwartzberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Journal of medical economics     Volume:  -     ISSN:  1941-837X     ISO Abbreviation:  J Med Econ     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9892255     Medline TA:  J Med Econ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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