| Relationship between GLP-1 levels and dipeptidyl peptidase-4 activity in different glucose tolerance conditions. | |
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MedLine Citation:
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PMID: 20546289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The reduced levels of glucagon-like peptide 1 (GLP-1) after an oral glucose load in Type 2 diabetic patients could be dependent either on a reduced synthesis or an increased degradation; but GLP-1 and dipeptidyl peptidase IV (DPP-IV) levels during an oral glucose tolerance test (OGTT) have not been studied together. The aim of the present study was to investigate GLP-1 and DPP-IV levels during an OGTT in patients with different degrees of glucose tolerance. METHODS: Fifty six subjects (34 female, 22 male) matched for sex, age, body mass index (BMI) and waist circumference underwent a 75 g oral glucose tolerance test. Twenty-eight had normal glucose tolerance, 15 had impaired glucose tolerance and 13 had Type 2 diabetes mellitus. GLP-1 assay was performed with an ELISA kit, and DPP-IV assay using a colorimetric method. RESULTS: At 30 min GLP-1 levels were significantly lower in subjects with impaired glucose tolerance and type 2 diabetes mellitus compared to those with normal glucose tolerance. The area under the GLP-1 curve was significantly different among the three groups; there was a significant decrease between subjects with normal and impaired glucose tolerance(P = 0.004) and between those with normal glucose tolerance and type 2 diabetes mellitus. (P < 0.001), while the area under the curve for DPP-IV showed no significant difference between the groups. CONCLUSIONS: These results suggest that an increase of GLP-1 degradation does not play a role in the early stages of diabetes mellitus. |
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Authors:
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L Pala; S Ciani; I Dicembrini; G Bardini; B Cresci; A Pezzatini; S Giannini; E Mannucci; C M Rotella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 27 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 691-5 Citation Subset: IM |
Affiliation:
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Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Area Under Curve Body Mass Index Diabetes Mellitus, Type 2 / metabolism* Dipeptidyl Peptidase 4 / metabolism* Fasting / metabolism Female Glucagon-Like Peptide 1 / metabolism* Glucose Tolerance Test Humans Male Middle Aged Waist Circumference |
| Chemical | |
Reg. No./Substance:
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89750-14-1/Glucagon-Like Peptide 1; EC 3.4.14.5/Dipeptidyl Peptidase 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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