| Relationship between Focal Inflammation and Symptom Exacerbation after Endovascular Coil Embolization for Symptomatic Intracranial Aneurysms. | |
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MedLine Citation:
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PMID: 20557759 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Summary: As endovascular surgery (EVS) of symptomatic unruptured aneurysms can result in symptom exacerbation due to intra-aneurysmal thrombosis or lump formation by coils, this treatment remains controversial. We present five women ranging in age from 58 to 76 years (mean 65.6 years) who suffered post-EVS symptom exacerbation attributable to local inflammation. The aneurysms measured from 8 to 25 mm (mean 19 mm) and were located at the cavernous portion in four patients and at the origin of the ophthalmic artery in one. All underwent endosaccular embolization under local anesthesia. Immediately after embolization, 24 h anticoagulation therapy was started via the continuous injection of heparin; they also received antiplatelet therapy. At one to three days post-EVS, all five patients manifested worsening of their cranial nerve symptoms. In three other patients the symptoms were improved after EVS. We posit that inflammation induced by coil embolization may worsen cranial nerve symptoms transiently. Our findings suggest that post-EVS followup is necessary and that patients exhibiting aninflammatory reaction be treated with anti-inflammatory drugs. |
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Authors:
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S Suzuki; A Kurata; K Iwamoto; M Yamada; J Niki; T Miyazaki; H Oka; K Fujii; S Kan |
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Publication Detail:
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Type: Journal Article Date: 2008-06-30 |
Journal Detail:
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Title: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Volume: 14 ISSN: 1591-0199 ISO Abbreviation: Interv Neuroradiol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602695 Medline TA: Interv Neuroradiol Country: Italy |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: - |
Affiliation:
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Department Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan - ssachio@med.kitasato-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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