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The Relationship between Estimated Cardiac Output and Cardiovascular Profile Score in High Output Lesions in the Fetus.
MedLine Citation:
PMID:  23001941     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: High cardiac output lesions are associated with an increased risk of fetal death due largely to cardiac failure and hydrops fetalis. The cardiovascular profile score (CVPS) has been used to characterize cardiovascular well-being, and related to fetal outcomes inother fetal conditions. We hypothesized that elevated combined cardiac output (CCO) in fetuses with high output lesions will be associated with worsening cardiovascular status, as evidenced by alower CVPS. Methods: A retrospective review of fetuses undergoing echocardiography with high cardiac output lesions between July of 2006 and November of 2010 was performed. Diagnoses included sacrococcygeal teratoma, placental chorioangioma, and vein of Galen aneurysm. Fetal echocardiographic evaluation included assessment of CVPS, as well as Doppler/2D estimation of CCO, indexed to estimated fetal weight. The relationship between CCO and CVPS was assessed. Results: A total of 35 fetuses were studied: 27 sacrococcygeal teratomas, 7 chorioangiomas, and 1 vein of Galen aneurysm. There is a significant inverse relationship between mean logCCOiand CVPS (r(2) = 0.48, p = 0.008). Of 30 patients with clinical outcome data, 10 experienced either in utero demise or intervention; 80% of these fetuses had a CVPS < 8. Conclusions: There is an inverse relationship between CCO and CVPS in the fetus with high cardiac output lesions. As a measure of fetal cardiovascular well-being in this population, the CVPS may be a useful tool for stratifying risk and for selection for intervention in these fetuses. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Christopher J Statile; James F Cnota; Susan Gomien; Allison Divanovic; Timothy Crombleholme; Erik Michelfelder
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Cincinnati Children's Hospital Medical Center. Christopher.statile@cchmc.org.
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