| Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. | |
| | |
MedLine Citation:
|
PMID: 21300369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine whether arterial stiffness relates to left ventricular mass (LVM) in adolescents and young adults. STUDY DESIGN: Demographic, anthropometric, laboratory, echo, carotid ultrasound and arterial stiffness data were obtained in 670 subjects 10 to 24 years of age (35% male, 62% non-Caucasian). Global stiffness index (GSI) was calculated from five measures of carotid artery stiffness, augmentation index, brachial distensibility, and pulse wave velocity (1 point if ≥95th% for subjects with body mass index <85th%). Stiff arteries (S = 73) were defined as GSI ≥95th%. Differences between flexible (F = 597) and S groups were evaluated by t tests. Models were constructed to determine whether GSI was an independent determinant of LVM index or relative wall thickness (RWT). RESULTS: The S group had more adverse cardiovascular risk factors, higher LVM index and RWT (P ≤ .05) with a trend for abnormal cardiac geometry. Independent determinants of LVM index were higher GSI, age, body mass index, systolic blood pressure, heart rate, glycated hemoglobin A1c, male sex, and sex-by-heart rate interaction (r(2) = 0.52; P ≤ .05). GSI was also an independent determinant of RWT. CONCLUSIONS: Increased arterial stiffness in adolescents and young adults is associated with LVM index independently of traditional cardiovascular risk factors. Screening for arterial stiffness may be useful to identify high risk adolescents and young adults. |
| | |
Authors:
|
Elaine M Urbina; Lawrence M Dolan; Connie E McCoy; Philip R Khoury; Stephen R Daniels; Thomas R Kimball |
Related Documents
:
|
12712019 - Transesophageal echocardiography follow-up of patients undergoing replacement of the as... 1380489 - Indigenous silicone rubber endoprosthesis for malignant esophago-pulmonary fistula. 8235789 - Internal closure of an aspergilloma cavity: report of a new technique and review of the... 16047119 - An uncommon coronary artery fistula causing survived sudden cardiac death in a young wo... 17670079 - Closure of a bronchopleural fistula using a fibrin-glue coated collagen patch. 10743889 - Increasing use of autogenous fistulas: selection of dialysis access sites by duplex sca... 14529249 - Femoral vessel injuries in modern warfare since vietnam. 3333009 - The carotid web: a developmental anomaly of the brachiocephalic system. 15772729 - Successful embolization of an ovarian artery pseudoaneurysm complicating obstetric hyst... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-12 Completed Date: 2011-06-16 Revised Date: 2012-05-02 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 715-21 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Pediatrics, Cincinnati Children's Hospital & University of Cincinnati, Cincinnati, OH, USA. Elaine.Urbina@cchmc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Blood Pressure / physiology Body Mass Index* Cardiovascular Diseases / epidemiology, etiology, physiopathology* Carotid Arteries / physiopathology*, ultrasonography Child Echocardiography Female Heart Ventricles / physiopathology, ultrasonography* Humans Incidence Male Obesity / complications*, epidemiology, physiopathology Risk Factors Sex Factors United States / epidemiology Vascular Resistance / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL076269/HL/NHLBI NIH HHS; R01 HL076269-04/HL/NHLBI NIH HHS; R01 HL105591-02/HL/NHLBI NIH HHS; UL1 RR026314/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
|
J Pediatr. 2011 May;158(5):709-714.e1
[PMID:
21147488
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Imidazolium camphorsulfonamides: Chiral catanionic liquid crystals with tunable thermal properties.
Next Document: Identification of Pneumothorax in Very Preterm Infants.