Document Detail

Relationship between diastolic perfusion pressure and progressive optic neuropathy as determined by Heidelberg retinal tomography topographic change analysis.
MedLine Citation:
PMID:  23258152     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine through retrospective file analysis which clinical factors best predict glaucomatous optic neuropathy as evaluated by Heidelberg retinal tomography (HRT II) imaging.
METHODS: One HUNDRED twenty-two records from patients referred for HRT imaging at the University of Waterloo Ocular Heath Clinic met inclusion criteria for this study and were reviewed. Topographic change analysis (TCA) data generated by HRT were examined in addition to the following clinical information: diastolic blood pressure, right arm sitting, intraocular pressure, and central corneal thickness. All HRT scans included were required to have 20 μm or better standard deviation (SD) on acquisition and deemed "very good" quality or "excellent" by HRT software. Based on previously defined published HRT TCA change criteria, each patient was allocated to one of the following groups: stable, borderline, or progressive.
RESULTS: Diastolic perfusion pressure (DPP) was found to be significantly lower in the borderline and progressive groups compared with the stable group (P < 0.001). DPP was also lower significantly lower in the progressive group compared with the borderline group (P < 0.001).
CONCLUSIONS: Low DPP appears to be a reasonable predictor of progressive optic neuropathy as determined using scans of <20 μm SD on the HRT TCA platform. DPP of 56 mm Hg or lower appears to be a clinically useful threshold to identify patients at increased risk of progressive optic neuropathy.
Patrick Quaid; Trefford Simpson; Thomas Freddo
Publication Detail:
Type:  Journal Article     Date:  2013-01-28
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-04-05     Revised Date:  2013-08-08    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  789-98     Citation Subset:  IM    
University of Waterloo School of Optometry & Vision Science, Canada.
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MeSH Terms
Blood Pressure / physiology*
Cornea / pathology
Corneal Pachymetry
Diagnostic Techniques, Ophthalmological
Disease Progression
Glaucoma, Open-Angle / diagnosis,  physiopathology*
Intraocular Pressure / physiology
Middle Aged
Optic Nerve Diseases / diagnosis,  physiopathology*
ROC Curve
Retrospective Studies
Risk Factors
Tomography / methods
Tonometry, Ocular

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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