| Relationship between Diastolic Perfusion Pressure and Progressive Optic Neuropathy as determined by HRT Topographic Change Analysis. | |
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MedLine Citation:
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PMID: 23258152 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To determine using retrospective file analysis which clinical factors best predicted glaucomatous optic neuropathy as determined using Heidelberg Retinal Tomography (HRT II) imaging. METHODS: 122 records meeting inclusion criteria for this study were reviewed from patients referred for HRT imaging at the University of Waterloo Ocular Heath Clinic (UWOHC). Topographic Change Analysis (TCA) data generated by the HRT in addition to the following clinical information was examined: diastolic blood pressure, right arm sitting (DBP, RAS), intraocular pressure (IOP) and central corneal thickness (CCT). All HRT scans included were required to have 20 microns or better standard deviation (SD) on acquisition and deemed "Very Good" quality or "Excellent" by HRT software. Using previously defined published HRT TCA change criteria each patient was allocated to one of the following groups (i) STABLE (ii) BORDERLINE or (iii) PROGRESSIVE. RESULTS: Diastolic perfusion pressure (DPP) was found to be significantly lower in the BORDERLINE group and PROGRESSIVE group compared to the STABLE group (p<0.001). DPP was also lower significantly lower in the PROGRESSIVE group compared to BORDERLINE group (p<0.001). CONCLUSIONS: Low DPP appears to be a reasonable predictor of progressive optic neuropathy as determined using scans of <20 microns SD on the HRT TCA platform. DPP of 56mmHg or lower appears to be a useful threshold clinically to identify those patients at increased risk of progressive optic neuropathy. |
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Authors:
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Patrick Quaid; Trefford Simpson; Thomas Freddo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-20 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Optometry &. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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